Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5‐fluorouracil

In this study, amino‐functionalized mesoporous silica (MS) particles were synthesized and loaded with the anticancer drug, 5‐Fu. In a post‐modification reaction, the pores were gated by an azobenzene derivative to act as an enzyme‐responsive drug delivery system. The synthesis and characterization o...

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Bibliographic Details
Published in:AIChE journal 2022-12, Vol.68 (12), p.n/a
Main Authors: Farjadian, Fatemeh, Moghadam, Maryam, Monfared, Mohammad, Mohammadi‐Samani, Soliman
Format: Article
Language:English
Subjects:
5-Fluorouracil
5‐flourouracil
Adsorption
Antitumor agents
Azo compounds
Azoreductase
Controlled release
Cytotoxicity
Dithionite
Drug delivery
Drug delivery systems
enzyme responsive
Evaluation
mesoporous silica
Reducing agents
Silica
Silicon dioxide
smart
Sodium
Sodium dithionite
Structural analysis
Toxicity
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Summary:In this study, amino‐functionalized mesoporous silica (MS) particles were synthesized and loaded with the anticancer drug, 5‐Fu. In a post‐modification reaction, the pores were gated by an azobenzene derivative to act as an enzyme‐responsive drug delivery system. The synthesis and characterization of the MS structure were validated using various instrumental techniques such as XRD, N2 adsorption/desorption, and FE‐SEM and TEM. The loading efficiency and capacity of 5‐Fu adsorption onto MS were evaluated; the adsorption isotherm graphs were plotted. The enzyme responsiveness feature of this nanocarrier was tested in the 5‐Fu release study. The 5‐Fu release from MS and the azo‐capped compound was measured, and when sodium dithionite was used as a reducing agent and an azoreductase enzyme mimicker, the controlled release was observed. Finally, the cytotoxicity of 5‐Fu loaded and azo‐capped MS in normal medium and sodium dithionate‐containing medium was evaluated and compared with the cytotoxicity of the free drug.
ISSN:0001-1541
1547-5905
DOI:10.1002/aic.17900