Convergence properties of platelets as mediators of the atherogenesis's inflammatory response in atherosclerosis risk groups

• Main Authors: Wihastuti, Titin Andri, Chomsy, Indah Nur, Permana, Andi, Kumboyono, Kumboyono
• Format: Conference Proceeding
• Language: English
• Subjects: Analyzers; Atherosclerosis; Blood; Blood platelets; Inflammatory response; Pathogenesis; Platelets; Risk
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0099194

Background: Atherosclerosis is a major cause of vascular disease worldwide, with its prevalence increasing every year. The pathogenesis of atherosclerosis is derived from the inflammatory response triggered by inflammatory cells, platelets. The inflammatory response in atherosclerosis originates from a mediator known as Lipoprotein-associated phospholipase A2 (Lp-PLA2). The role of platelets in atherosclerosis is for platelet aggregation and thrombus formation. The role of Lp-PLA2 in the inflammatory response to atherogenesis is still controversial. Purpose: This study aimed to determine the correlation between Lp-PLA2 levels and platelet levels in conditions at risk of atherosclerosis. Methods: This study was descriptive-analytic and used venous blood samples taken from 86 patients at risk of atherosclerosis. The venous blood sample was taken and measured using the Automated Haematology Analyzers for platelet count and ELISA to measure Lp-PLA2 level in the blood sample. Results & Discussion: The relationship between platelet levels and Lp-PLA2 levels, (0.089 5% significance level (p-value=0.417). Platelet levels are indeed through different mechanisms in triggering the inflammatory response, but, certainly, the two work together in causing chronic inflammation in the pathogenesis of atherosclerosis. Conclusion: There is an insignificant/weak relationship between platelet levels and Lp-PLA2 levels, but the correlation between platelets and Lp-PLA2 levels in the blood is positive.