USE OF THE INTESTINAL BARRIER INJURY BIOMARKER (I-FABP) FOR DIAGNOSTICS AND PREDICTION OF ACUTE PANCREATITIS

Introduction: In patients with acute pancreatitis (AP), the digestive tract (DT) is quite vulnerable, the occurrence of its dysfunction plays a significant role in the development of complications of the disease, which is also observed in other emergency conditions [1]. The severity of DT dysfunctio...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2022-11, Vol.22, p.e10-e10
Main Authors: Kryvoruchko, Igor A., Drozdova, A., Goncharova, N.
Format: Article
Language:English
Subjects:
Abdomen
Biomarkers
Enterocytes
Fatty acid-binding protein
Gastrointestinal tract
Intensive care
Intensive care units
Mortality
Pancreatitis
Patients
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Summary:Introduction: In patients with acute pancreatitis (AP), the digestive tract (DT) is quite vulnerable, the occurrence of its dysfunction plays a significant role in the development of complications of the disease, which is also observed in other emergency conditions [1]. The severity of DT dysfunction often indicates the severity of the condition of critical patients, since several publications have reported that almost 50% of patients in intensive care units (ICUs) have damage to enterocytes at the initial stage of treatment [2], and among seriously ill patients with PT dysfunction often leads to high mortality rates [3, 4]. Results: The level of I-FABP in the serum after 48 hours increased by 69.8% on average, showed good accuracy for predicting the damage severity to the digestive tract after 48 hours compared with the initial level of AGI grade (area under the ROC curve 0.913) at the threshold value I-FABP 1350 pg/ml with a sensitivity of 0.95 and a specificity of 0.9.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2022.06.031