Indole Alkaloids from the Cigar Tobacco-Derived Endophytic Fungus Aspergillus oryzae and Their Antibacterial Activity

Two new indole alkaloids, 6-(4-methoxyphenoxy)-4-methoxy-2-methyl-1 H -indole ( 1 ) and 6-(3,5-dimethoxyphenoxy)-4-methoxy-2-methyl-1 H -indole ( 2 ), along with four known ones ( 3–6 ), were isolated from the fermentation products of the cigar tobacco-derived endophytic fungus Aspergillus oryzae ....

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Published in:Chemistry of natural compounds 2022-11, Vol.58 (6), p.1093-1097
Main Authors: Li, Man-fei, Xiao, Dong, Zhu, Ling-Chao, Liu, Lu, Zheng, Jun-Na, Gu, Xue-Jiao, Zhu, Ya-Ning, Xie, Jiao, Wang, Xu, Dai, Jia-Meng, Mi, Qi-Li, Yang, Ye-Kun, Hu, Qiu-Fen, Li, Yin-Ke, Shi, Jian-Quan
Format: Article
Language:English
Subjects:
Alkaloids
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Fungi
Methicillin
NMR
Nuclear magnetic resonance
Organic Chemistry
Plant Sciences
Tobacco
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Summary:Two new indole alkaloids, 6-(4-methoxyphenoxy)-4-methoxy-2-methyl-1 H -indole ( 1 ) and 6-(3,5-dimethoxyphenoxy)-4-methoxy-2-methyl-1 H -indole ( 2 ), along with four known ones ( 3–6 ), were isolated from the fermentation products of the cigar tobacco-derived endophytic fungus Aspergillus oryzae . Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their antibacterial and antioxidant activities. The results showed that compounds 1 and 2 exhibited good anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity with IZD of 22.4 ± 2.4 and 24.6 ± 2.2 mm, respectively.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-022-03872-x