Antimicrobial Effects of Tetraspanins: A New Turnabout in Treatment of Microorganisms

The Ministry of Health (2) in Malaysia had reported that most bacteria develop resistance towards common antibiotics such as ciprofloxacin, cefotaxime and ampicillin ranging from 10% to 50% among different bacterial species. [...]it is imperial to discover and plan new strategies as effective treatm...

Full description

Saved in:
Bibliographic Details
Published in:The Malaysian journal of medical sciences 2022-08, Vol.29 (4), p.6-13
Main Authors: Murad, Khairiyah, Rahim, Sharaniza A B, Al-Talib, Hassanain
Format: Article
Language:English
Subjects:
Amino acids
Antibiotics
Antimicrobial agents
Bacterial infections
Binding sites
Drug resistance
E coli
Hepatitis C
Lipids
Monoclonal antibodies
Pathogens
Proteins
Salmonella
Streptococcus infections
Viral infections
Viruses
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Ministry of Health (2) in Malaysia had reported that most bacteria develop resistance towards common antibiotics such as ciprofloxacin, cefotaxime and ampicillin ranging from 10% to 50% among different bacterial species. [...]it is imperial to discover and plan new strategies as effective treatments to combat microbial resistance. Structure and Modifications of Tetraspanins The basic structural components of tetraspanins consist of four hydrophobic transmembrane domains with cytoplasmic and extracellular loops alongside intracellular N- and C-termini (3, 6). Tetraspanins are well documented to be associated with the hepatitis C virus and human immunodeficiency virus (HIV) for viral entry into the host cells (5). The combination of anti-tetraspanin monoclonal antibodies (anti-CDç, anti-CD63 and anti-CD151) has been shown to significantly reduced the bacterial cell adherence of Neisseria lactamica, Escherichia coli and Streptococcus pneumoniae (10).
ISSN:1394-195X
2180-4303
DOI:10.21315/mjms2022.294.2