Synthesis of copolymer eugenol-trithiol-divinylbenzene via photoinitiated cross-linking reaction as antibacterial compound

The Copolymer networks derived from eugenol and divinylbenzene was carried out through the photoactivated thiol-ene reaction. Divinylbenzene with two vinyl groups indicated can be a good cross-linker to form copolymer compound. Meanwhile, eugenol the main material from the copolymer is being known t...

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Main Authors: Ngadiwiyana, Laksana, Dihan Vigy, Bima, Damar Nurwahyu, Ismiyarto, Sarjono, Purbowatiningrum Ria, Prasetya, Nor Basid Adiwibawa
Format: Conference Proceeding
Language:English
Subjects:
Antibacterial materials
Chemical properties
Chemical reactions
Chemical synthesis
Copolymers
Crosslinking
Divinylbenzene
E coli
Penicillin
Tensile strength
Thiols
Ultraviolet radiation
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Summary:The Copolymer networks derived from eugenol and divinylbenzene was carried out through the photoactivated thiol-ene reaction. Divinylbenzene with two vinyl groups indicated can be a good cross-linker to form copolymer compound. Meanwhile, eugenol the main material from the copolymer is being known to have an excellent potential of antibacterial activity. The photoactivated thiol-ene reaction is a fast and straightforward method to prepare new material with advanced physical and chemical properties as an antibacterial agent. The mixtures were irradiated with UV light and produce a transparent resin film. The thiol-ene reaction of copolymer network E-3T-DVB was successfully carried out as seen from FTIR spectra where the intensity of the -SH group in 2577 cm−1 and C=C group in 1657 cm−1 decreased after being irradiated by UV light. The presence of copolymer product was characterized using FTIR, TGA, and tensile strength to obtain the physical and chemical properties of the copolymer. The antibacterial activity of the copolymer network E-3T-DVB was investigated against Escherichia coli and Staphylococcus aureus by turbidimetric method. The copolymer was more effective in inhibiting E. Coli than S. Aureus, with the perform inhibition of bacterial growth from E. Coli and S. Aureus of 72.9% and 0.6%, respectively for 12 h incubation time, while for 24 h incubation time, the copolymer ability to inhibit the bacterial growth of Escherichia coli and Staphylococcus aureus are 9.3% and 47.1%, respectively.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0103667