Comparison of dose volumetric parameters of oesophagus in the radiation treatment of carcinoma breast with and without oesophagus delineation

Aim:There are only limited studies available in literature that discuss methods to reduce the oesophageal dose and acute oesophagitis during breast cancer radiotherapy. The aim of this study is to compare dose volumetric parameters of oesophagus in radiation treatment of breast with and without oeso...

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Bibliographic Details
Published in:Journal of radiotherapy in practice 2023-01, Vol.22, Article e10
Main Authors: Bhaskaran, Reshma, Pulickal, Sajeev George, Reghu, Harikrishnan, Perumangat, Aparna, Moolath, Girish Babu
Format: Article
Language:English
Subjects:
Breast cancer
Clavicle
Conformity
Contouring
Delineation
Dosimetry
Esophagitis
Esophagus
Homogeneity
Irradiation
Lungs
Mastectomy
Original Article
Parameters
Patients
Planning
Radiation
Radiation therapy
Statistical analysis
Toxicity
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Summary:Aim:There are only limited studies available in literature that discuss methods to reduce the oesophageal dose and acute oesophagitis during breast cancer radiotherapy. The aim of this study is to compare dose volumetric parameters of oesophagus in radiation treatment of breast with and without oesophagus delineation.Methods:Treatment plans of 44 patients, who underwent chest wall and supraclavicular fossa irradiation, were selected for the study. Oesophagus was later delineated and treatment replanned using three-dimensional conformal radiotherapy (3DCRT) considering oesophagus as an organ at risk (OAR). The dose prescribed was 40 Gy/15 fractions to the planning target volume (PTV). Dose volumetric parameters of oesophagus such as maximum dose (Dmax), mean dose (Dmean), the percentage of oesophagus volume receiving ≥15Gy (V15), ≥25Gy(V25), ≥33Gy(V33) and ipsilateral lung volume parameters V4, V8 and V16 were compared with already executed plans in which oesophagus was not delineated.Results:Contouring the oesophagus as an OAR as a part of the radiotherapy treatment for Carcinoma Breast resulted in statistically significant reduction in dose to the oesophagus. No statistically significant change was found in the ipsilateral lung volume parameters. No compromise in plan quality was required as evident from the statistically non-significant differences in Homogeneity index and Conformity index.Findings:3DCRT planning with oesophagus delineation can be considered as a method to reduce oesophageal dose and the acute oesophageal toxicity during radiotherapy for carcinoma breast.
ISSN:1460-3969
1467-1131
DOI:10.1017/S1460396921000467