Triclosan-containing sutures: safety and resistance issues need to be addressed prior to generalized use

Triclosan (TCS), a synthetic antimicrobial, has been incorporated into a variety of personal care products worldwide. Since 2016, upon the recommendation of World Health Organization (WHO), the use of TCS-containing sutures (TCSCS) to prevent surgical site infections (SSI) has become a common practi...

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Bibliographic Details
Published in:Applied nanoscience 2022-11, Vol.12 (11), p.3061-3070
Main Authors: Khan, Raees, Yee, Alyson L., Gilbert, Jack A., Haider, Adnan, Jamal, Syed Babar, Muhammad, Fawad
Format: Article
Language:English
Subjects:
Chemistry and Materials Science
Hazard assessment
Infectious diseases
Materials Science
Membrane Biology
Nanochemistry
Nanotechnology
Nanotechnology and Microengineering
Public health
Review Article
Safety
Surgery
Sutures
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Summary:Triclosan (TCS), a synthetic antimicrobial, has been incorporated into a variety of personal care products worldwide. Since 2016, upon the recommendation of World Health Organization (WHO), the use of TCS-containing sutures (TCSCS) to prevent surgical site infections (SSI) has become a common practice. However, TCS is a subject of environmental and public health concern and has been ranked as a chemical of serious concern to be avoided based on GreenScreen ® hazard assessment. Recent reports on the efficacy of TCSCS to prevent SSI have revealed conflicting results. Here, we aim to highlight and discuss various safety and antimicrobial resistance concerns associated with the generalized use of TCSCS. Further, we emphasize that the long-term health benefits must be evaluated before the incorporation of TCS into surgical sutures.
ISSN:2190-5509
2190-5517
DOI:10.1007/s13204-021-01979-1