L-ascorbic acid and α-tocopherol treatment alleviates parabenzoquinone-induced hemato-biochemical and histopathological changes in Wistar rats

Objective The effect of L-ascorbic acid and α-tocopherol on parabenzoquinone(p-BQ)-induced hemato-biochemical and histological alterations in the liver and kidney of male Wistar rats was investigated. Material and methods Animals ( n  = 40) were divided into eight groups, all receiving p-BQ(1.5 mg K...

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Bibliographic Details
Published in:Toxicology and environmental health sciences 2022-12, Vol.14 (4), p.379-387
Main Authors: Mishra, Ritu, Dutta, Karabi, Bharali, Manuj Kr
Format: Article
Language:English
Subjects:
Acids
Animals
Antioxidants
Ascorbic acid
Biochemistry
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cholesterol
Combined treatment
Creatinine
Distilled water
Environmental Health
High density lipoprotein
Kidneys
Leukocytes (neutrophilic)
Lipid peroxidation
Lipids
Liver
Low density lipoprotein
Lymphocytes
Original Article
Peroxidation
Pharmacology/Toxicology
Rodents
Tocopherol
Toxicity
Triglycerides
Urea
Vitamin C
Vitamin E
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Summary:Objective The effect of L-ascorbic acid and α-tocopherol on parabenzoquinone(p-BQ)-induced hemato-biochemical and histological alterations in the liver and kidney of male Wistar rats was investigated. Material and methods Animals ( n  = 40) were divided into eight groups, all receiving p-BQ(1.5 mg Kg −1 , i.p) for 21 days except the control group I which received equal amount of double-distilled water only. Group II served as positive control group, while all other groups received either L-ascorbic acid or α-tocopherol or combination of both L-ascorbic acid and α-tocopherol for 21 consecutive days. Results p-BQ significantly ( P  
ISSN:2005-9752
2233-7784
DOI:10.1007/s13530-022-00152-7