unique late-replicating XY to autosome translocation in Peromyscus melanophrys

We report on the characterization of the Peromyscus melanophrys karyotype and sex chromosome system. Classic studies reported the sex chromosome system of this species may be as complex as an X₁X₁X₂X₂/X₁X₂Y₁Y₂ and provided conflicting identification of the X chromosome. Using Peromyscus maniculatus...

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Bibliographic Details
Published in:Chromosome research 2010-02, Vol.18 (2), p.179-189
Main Authors: Mlynarski, Elisabeth E, Obergfell, Craig, Dewey, Michael J, O'Neill, Rachel J
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Cell Biology
Chromosome Painting
Chromosomes
Deoxyribonucleic acid
DNA
DNA Replication
Female
Genomics
Heterochromatin - metabolism
Human Genetics
Life Sciences
Male
Peromyscus - genetics
Plant Genetics and Genomics
Translocation, Genetic
X Chromosome
X Chromosome Inactivation
Y Chromosome
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Summary:We report on the characterization of the Peromyscus melanophrys karyotype and sex chromosome system. Classic studies reported the sex chromosome system of this species may be as complex as an X₁X₁X₂X₂/X₁X₂Y₁Y₂ and provided conflicting identification of the X chromosome. Using Peromyscus maniculatus chromosome paints, we have positively identified the sex chromosomes and clarified the sex determining system that once perplexed Peromyscus researchers. The sex chromosomes are characterized by a unique autosomal translocation of DNA shared between both the X and Y chromosomes. The translocated material is late replicating and heterochromatic yet retains the active chromatin conformation. Thus, autosomal regions derived from translocations involving repeat-rich material may retain some epigenetic marks specific to the sex chromosomes despite loss of epigenetic silencing activity.
ISSN:0967-3849
1573-6849
DOI:10.1007/s10577-010-9113-3