Bleomycin-Induced Fulminant Hyperpyrexia: A Report of Two Cases and Review of Literature

Bleomycin is a commonly used cytotoxic agent that has proven its efficacy over the years. Though a common part of many protocols targeting lymphomas and germ cell tumors, it does have some serious adverse effects. Bleomycin is notorious for pulmonary toxicity and very rarely may cause fulminant hype...

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Published in:Curēus (Palo Alto, CA) CA), 2022-09, Vol.14 (9)
Main Authors: Jhatial, Mussadique Ali, Bin Naeem, Sameen, Abbas, Mansoor, Baloch, Naqib Ullah, Bokhari, Syed W, Ahsan, Bushra, Ahmad, Usman, Masood Sheikh, Rizwan
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Blood pressure
Case reports
Chemotherapy
Disease
Drug dosages
Enzymes
Fever
Heart rate
Hemoglobin
Hepatitis C
Intensive care
Lymphoma
Medical imaging
Pleural effusion
Tomography
Ultrasonic imaging
Ventilators
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container_issue 9
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container_title Curēus (Palo Alto, CA)
container_volume 14
creator Jhatial, Mussadique Ali
Bin Naeem, Sameen
Abbas, Mansoor
Baloch, Naqib Ullah
Bokhari, Syed W
Ahsan, Bushra
Ahmad, Usman
Masood Sheikh, Rizwan
description Bleomycin is a commonly used cytotoxic agent that has proven its efficacy over the years. Though a common part of many protocols targeting lymphomas and germ cell tumors, it does have some serious adverse effects. Bleomycin is notorious for pulmonary toxicity and very rarely may cause fulminant hyperpyrexia. We describe two cases of classical Hodgkin’s lymphoma (cHL) developing acute fulminant hyperpyrexia after administration of the first dose of bleomycin as part of chemotherapy protocol. This is a rare adverse reaction that closely mimics anaphylaxis and has an unpredictable and possibly fatal course. Health care professionals involved in the administration of chemotherapy need to be very vigilant in monitoring for symptoms of this reaction.
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subjects Antibodies
Antigens
Blood pressure
Case reports
Chemotherapy
Disease
Drug dosages
Enzymes
Fever
Heart rate
Hemoglobin
Hepatitis C
Intensive care
Lymphoma
Medical imaging
Pleural effusion
Tomography
Ultrasonic imaging
Ventilators
title Bleomycin-Induced Fulminant Hyperpyrexia: A Report of Two Cases and Review of Literature
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