Polymeric Micelles for Targeted Drug Delivery System

Targeted drug transport is becoming more and more popular for increasing the efficiency of interactions between a drug and a target. This method allows the drug concentration to be increased at a desired site and to block or strongly limit drug accumulation in healthy organs and tissues. Micelle-bas...

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Bibliographic Details
Published in:Applied biochemistry and microbiology 2022-12, Vol.58 (6), p.726-737
Main Authors: Guliy, O. I., Staroverov, S. A., Fomin, A. S., Zhnichkova, E. G., Kozlov, S. V., Lovtsova, L. G., Dykman, L. A.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Drug delivery
Drug delivery systems
Internalization
Life Sciences
Medical Microbiology
Micelles
Microbiology
Organs
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Summary:Targeted drug transport is becoming more and more popular for increasing the efficiency of interactions between a drug and a target. This method allows the drug concentration to be increased at a desired site and to block or strongly limit drug accumulation in healthy organs and tissues. Micelle-based nanopreparations can be considered as a system with unique characteristics compared to other nanocarriers, since the smaller size allows passive targeting of target organs (even poorly permeable ones) and efficient internalization by cells. Polymeric micelles are increasingly being used to create drug delivery systems. This paper presents a brief overview of the production of polymeric micelles, the release of the drug, and the possibility of their practical application.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683822060059