Long non-coding RNA opa-interacting protein 5 antisense transcript 1 (LncRNA OIP5-AS1) promoted cisplatin resistance in nasopharyngeal carcinoma via the miR-378a-3p/nicotinamide N-methyltransferase axis

LncRNAs involve in chemoresistance of human cancers. However, the role and molecular mechanisms of lncRNA OIP5-AS1 in the chemoresistance of NPC are still unexplored. In our study, upregulated OIP5-AS1 was found in cisplatin (CDDP)-resistant NPC tumors and cell lines. Functional assays revealed OIP5...

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Bibliographic Details
Published in:Materials express 2022-07, Vol.12 (7), p.980-987
Main Authors: Bai, Zhigang, Zhang, Dongli, Shi, Enhong
Format: Article
Language:English
Subjects:
Apoptosis
Cancer
Cisplatin Resistance
Mir-378a-3p
Nasopharyngeal Carcinoma
Nicotinamide
Nnmt
Oip5-As1
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Summary:LncRNAs involve in chemoresistance of human cancers. However, the role and molecular mechanisms of lncRNA OIP5-AS1 in the chemoresistance of NPC are still unexplored. In our study, upregulated OIP5-AS1 was found in cisplatin (CDDP)-resistant NPC tumors and cell lines. Functional assays revealed OIP5-AS1 knockdown suppressed malignant behaviors, but stimulated apoptosis of CDDP-resistant NPC cells. Furthermore, we demonstrated OIP5-AS1 positively regulated NNMT by directly targeting miR-378a-3p. In addition, its inhibition partially abolished the inhibitory effects of OIP5-AS1 silencing on malignancy of CDDPresistant NPC cells, whereas NNMT knockdown reverse these effects. In sum, our results indicated OIP5-AS1 contributed to the CDDP resistance of NPC by sponging miR-378a-3p to increase NNMT expression.
ISSN:2158-5849
2158-5857
DOI:10.1166/mex.2022.2219