Telomere, Telomerase and The Aging Heart

Aging is a physiological process in all populations with time and finally leads to cellular senescence and organ dysfunction. Telomere's primary function is the protection of DNA with the help of the telomerase enzyme. Telomerase activity declines with time, and with each cell division, telomer...

Full description

Saved in:
Bibliographic Details
Published in:The American heart journal 2022-12, Vol.254, p.243-243
Main Authors: Elsaeidy, Ahmed Saad, Kamal, Manar Ahmed, Sameh, Mostafa, Fouad, Ahmed Fady
Format: Article
Language:English
Subjects:
Aging
Arteriosclerosis
Atherogenesis
Atherosclerosis
Cardiovascular diseases
Cardiovascular system
Cell division
Congestive heart failure
Deoxyribonucleic acid
Diabetes mellitus
DNA
Environmental factors
Genetic factors
Health risks
Heart
Heart diseases
Hepatitis C
Hypertension
Ischemia
Oxidative stress
Pathogenesis
Physical activity
Risk analysis
Risk factors
Senescence
Telomerase
Telomeres
Viruses
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aging is a physiological process in all populations with time and finally leads to cellular senescence and organ dysfunction. Telomere's primary function is the protection of DNA with the help of the telomerase enzyme. Telomerase activity declines with time, and with each cell division, telomere length decreases. To review the association between short telomere and aging-related heart diseases. The previous literature was narratively reviewed. Overview of telomere length and cardiovascular diseases. Unique variations of telomere length are affected by genetic and non‐genetic factors. Genetic and environmental factors cause individual variation in telomere length (TL). A healthy lifestyle as a healthy diet and physical activity maintains TL, while hypertension, diabetes, atherosclerosis, Hepatitis C virus, and human immune deficiency virus are cardiovascular risk factors that increase oxidative stress, induce endothelial inflammation, and accelerate telomere shortening. Telomere shorting plays an essential role in the pathogenesis of aging-associated heart diseases. Short telomeres cause cellular senescence and dysfunction, contributing to atherogenesis and decreasing repair and regenerative capacity in the cardiovascular system. Telomere and telomerase are associated with heart aging. However, Telomerase and telomere-associated proteins, which regulate TL, may participate in the therapeutic strategies for ischemic heart diseases and heart failure.
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2022.10.031