Palladium-catalyzed interannular C-H amination of biaryl amines

A palladium-catalyzed interannular C-H amination of biaryl amines with O -benzoylhydroxylamines is reported. This reaction undergoes smoothly with operational practicality and good tolerance of functional groups, thereby providing a concise synthesis of 2,2′-diaminobiaryls. Moreover, the readily acc...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-12, Vol.58 (98), p.1362-13623
Main Authors: Wu, Jiaping, Sun, Pengpeng, Hong, Yuwen, Yang, Haitao, Xie, Meihua, Zhang, Jitan
Format: Article
Language:English
Subjects:
Amines
Functional groups
Palladium
Synthesis
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Summary:A palladium-catalyzed interannular C-H amination of biaryl amines with O -benzoylhydroxylamines is reported. This reaction undergoes smoothly with operational practicality and good tolerance of functional groups, thereby providing a concise synthesis of 2,2′-diaminobiaryls. Moreover, the readily accessible scale-up synthesis and the ability to transform the products into structurally diverse N-containing heterocycles demonstrate the synthetic potential of this catalytic protocol. A palladium-catalyzed interannular C-H amination of biaryl amines with O -benzoylhydroxylamines is reported, thus affording structurally diverse 2,2′-diaminobiaryls.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc05129j