The effect of bergamot (KoksalGarry) supplementation on lipid profiles: A systematic review and meta‐analysis of randomized controlled trials

This systematic review and meta‐analysis were conducted to evaluate the impact of bergamot (KoksalGarry) and its nutraceutical compounds on lipid profiles. PubMed, Web of Knowledge, Scopus, and Google Scholar searched for relevant articles. Trials investigating the effect of oral bergamot supplement...

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Bibliographic Details
Published in:Phytotherapy research 2022-12, Vol.36 (12), p.4409-4424
Main Authors: Sadeghi‐dehsahraei, Hamed, Esmaeili Gouvarchin Ghaleh, Hadi, Mirnejad, Reza, Parastouei, Karim
Format: Article
Language:English
Subjects:
bergamot
Cholesterol
Clinical trials
Density
Dietary supplements
Functional foods & nutraceuticals
High density lipoprotein
KoksalGarry
lipid profile
Lipids
Low density lipoprotein
Meta-analysis
Reviews
Search engines
Serum levels
Systematic review
Triglycerides
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Summary:This systematic review and meta‐analysis were conducted to evaluate the impact of bergamot (KoksalGarry) and its nutraceutical compounds on lipid profiles. PubMed, Web of Knowledge, Scopus, and Google Scholar searched for relevant articles. Trials investigating the effect of oral bergamot supplementation on serum levels of total cholesterol (TC), triglyceride (TG), low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C) in adults were included. The mean differences and standard deviations were pooled using a random‐effects model. Fourteen trials were included in this systematic review and meta‐analysis. Bergamot supplementation significantly decreased serum levels of TC (weighted mean difference (WMD): −63.60 mg/dL; 95% CI: −78.03 to −49.18; p 
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7647