Ultrasound-guided botulinum toxin A injection: an alternative treatment for dribbling

Dribbling (sialorrhoea) affects about 10 per cent of patients with chronic neurological disease. The variety of treatments currently available is unsatisfactory. This study was a clinical trial of the efficacy of ultrasound-guided, intraglandular injection of botulinum toxin A for dribbling, perform...

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Bibliographic Details
Published in:Journal of laryngology and otology 2008-06, Vol.122 (6), p.609-614
Main Authors: Marina, M B, Sani, A, Hamzaini, A H, Hamidon, B B
Format: Article
Language:English
Subjects:
Adolescent
Aged
Biological and medical sciences
Botulinum Toxin Type A
Botulinum Toxins, Type A - administration & dosage
Brain Diseases - complications
Child
Female
Humans
Injection
Injections - methods
Malaysia
Male
Medical sciences
Neurotoxins - administration & dosage
Non tumoral diseases
Otorhinolaryngology. Stomatology
Parotid Gland - drug effects
Patient Satisfaction
Salivary Gland
Sialorrhea - drug therapy
Sialorrhea - etiology
Sialorrhoea
Statistics, Nonparametric
Submandibular Gland - drug effects
Treatment Outcome
Ultrasonography
Ultrasonography, Interventional
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Dribbling (sialorrhoea) affects about 10 per cent of patients with chronic neurological disease. The variety of treatments currently available is unsatisfactory. This study was a clinical trial of the efficacy of ultrasound-guided, intraglandular injection of botulinum toxin A for dribbling, performed within the otorhinolaryngology department of the National University of Malaysia. Both pairs of parotid and submandibular glands received 25 U each of botulinum toxin A. Twenty patients were enrolled in the study. The median age was 15 years. All 20 patients (or their carers) reported a distinct improvement in symptoms after injection. Using the Wilcoxon signed rank test, there were significant reductions in dribbling rating score, dribbling frequency score, dribbling severity score, dribbling visual analogue score and towel changes score, comparing pre- and post-injection states (p
ISSN:0022-2151
1748-5460
1748-5640
DOI:10.1017/S0022215107008730