Silver and Silver Nanoparticles for the Potential Treatment of COVID-19: A Review

COVID-19 is an epizootic and life-threatening outbreak affecting millions of people globally. Coronavirus variants have emerged in different locations since their origin. Silver and its compounds, including silver nanoparticles (AgNPs), have been used in the medical field for a long period, especial...

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Bibliographic Details
Published in:Coatings (Basel) 2022-11, Vol.12 (11), p.1679
Main Authors: Arjun, Phalalochanan Nair Jayapal, Sankar, Bipin, Shankar, Karthik V, Kulkarni, Naveen V, Sivasankaran, Subbarayan, Shankar, Balakrishnan
Format: Article
Language:English
Subjects:
Antiviral agents
Binding
Coronaviruses
COVID-19
Disease transmission
Disinfection & disinfectants
Health aspects
Infections
Medical research
Methods
Microorganisms
Mortality
Nanoparticles
Pandemics
Respiratory diseases
Severe acute respiratory syndrome coronavirus 2
Silver
Silver compounds
Toxicity
Viral diseases
Viruses
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Summary:COVID-19 is an epizootic and life-threatening outbreak affecting millions of people globally. Coronavirus variants have emerged in different locations since their origin. Silver and its compounds, including silver nanoparticles (AgNPs), have been used in the medical field for a long period, especially in surgical treatments. The anti-microbial and anti-viral properties of silver are well documented. These properties depend on the size of the particles, concentration, precursor, method of preparation, and the presence of other benefiting compounds. Several experiments were conducted by researchers worldwide to prove the anti-bacterial and anti-viral properties of silver (Ag) and AgNPs, emphasizing that silver can be introduced to multiple organs in the human body and exhibit the expected antiviral characteristics. In this review article, use of silver nanoparticles to fight the COVID-19 pandemic according with the current information is discussed. The mechanisms involving antiviral activity and toxicity are discussed in detail. This article concludes that strong binding of AgNPs with SARS-CoV-2 virus prevents binding with the host cell, leading to the death of the virus. However, increased cytotoxic effect of the silver compounds at higher concentrations is a matter of concern.
ISSN:2079-6412
2079-6412
DOI:10.3390/coatings12111679