Effects of Low-Level Organic Mercury Exposure on Oxidative Stress Profile

Background: The fish-based diet is known for its potential health benefits, but it is less known for its association with mercury (Hg) exposure, which, in turn, can lead to neurological and cardiovascular diseases through the exacerbation of oxidative stress. The aim of this study was to evaluate th...

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Bibliographic Details
Published in:Processes 2022-11, Vol.10 (11), p.2388
Main Authors: Tincu, Radu Ciprian, Cobilinschi, Cristian, Florea, Iulia Alexandra, Cotae, Ana-Maria, Băetu, Alexandru Emil, Isac, Sebastian, Ungureanu, Raluca, Droc, Gabriela, Grintescu, Ioana Marina, Mirea, Liliana
Format: Article
Language:English
Subjects:
Age
Alcohol
Alfacalcidol
Analysis
Biomarkers
Blood
Blood levels
Calcifediol
Calciferol
Cardiovascular diseases
Ethylenediaminetetraacetic acid
Exposure
Glutathione
Glutathione peroxidase
Heavy metals
Lifestyles
Lymphocytes
Mercury
Outpatient care facilities
Oxidative stress
Peroxidase
Plasma levels
Selenium
Smoking
Superoxide
Superoxide dismutase
Toxicology
Variables
Vitamin D
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Summary:Background: The fish-based diet is known for its potential health benefits, but it is less known for its association with mercury (Hg) exposure, which, in turn, can lead to neurological and cardiovascular diseases through the exacerbation of oxidative stress. The aim of this study was to evaluate the correlations between Hg blood concentration and specific biomarkers for oxidative stress. Methods: We present a cross-sectional, analytical, observational study, including primary quantitative data obtained from 67 patients who presented with unspecific complaints and had high levels of blood Hg. Oxidative stress markers, such as superoxide dismutase (SOD), glutathione peroxidase (GPX), malondialdehyde (MLD), lymphocyte glutathione (GSH-Ly), selenium (Se), and vitamin D were determined. Results: We found positive, strong correlations between Hg levels and SOD (r = 0.88, p < 0.0001), GPx (r = 0.92, p < 0.0001), and MLD (r = 0.94, p < 0.0001). We also found inverted correlations between GSH-Ly and vitamin D and Hg blood levels (r = −0.86, r = −0.91, respectively, both with p < 0.0001). Se had a weak correlation with Hg plasma levels, but this did not reach statistical significance (r = −0.2, p > 0.05). Conclusions: Thus, we can conclude that low-level Hg exposure can be an inductor of oxidative stress.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr10112388