Effect of maternal adverse childhood experiences (ACE) and cannabis use on pregnancy outcomes

This study aimed to characterize the relationship between cannabis use, ACE score, and pregnancy outcomes. Pregnant patients in Baltimore, MD, completed the 17-point ACE checklist. Charts of the birth parent and neonate were reviewed for urine toxicology testing at initiation of care and delivery, p...

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Bibliographic Details
Published in:Archives of women's mental health 2022-12, Vol.25 (6), p.1097-1104
Main Authors: Klasner, Carson, Brown, Jessica, Gopalakrishnan, Mathangi, Metwally, Dina El, Besse, Margaret, Mark, Katrina
Format: Article
Language:English
Subjects:
Adverse Childhood Experiences
Birth Weight
Cannabis
Cannabis - adverse effects
Child abuse & neglect
Childbirth & labor
Childhood
Childhood factors
Children
Drug abuse in pregnancy
Female
Forecasts and trends
Health aspects
Humans
Infant, Newborn
Marijuana
Medicine
Medicine & Public Health
Mental health
Mothers
Original Article
Parents & parenting
Pregnancy
Pregnancy Outcome - epidemiology
Pregnancy, Complications of
Prenatal Care
Psychiatry
Psychotherapy
Statistical analysis
Substance abuse
Substance use
Womens health
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Summary:This study aimed to characterize the relationship between cannabis use, ACE score, and pregnancy outcomes. Pregnant patients in Baltimore, MD, completed the 17-point ACE checklist. Charts of the birth parent and neonate were reviewed for urine toxicology testing at initiation of care and delivery, prenatal care metrics, and birth statistics. Multivariable logistic regression analysis was performed to assess the relationship between ACE score, cannabis use, and pregnancy outcomes. Of 256 birth parents, 87 (34.0%) tested positive for cannabis at initial visit and 39 (15.2%) tested positive for cannabis at delivery. Testing positive for cannabis at initial visit or delivery was associated with higher ACE score (15.1 vs 13.7, p  = 0.04; 16.2 vs 13.8, p  = 0.01). Of those who tested positive for cannabis at initial visit, 39/87 (45.0%) tested positive at delivery. Continued cannabis use at delivery was associated with lower maternal weight gain (7.9 kg vs 13.3 kg, p  = 0.003), fewer prenatal visits (7 vs 8, p  = 0.010), and numerically higher mean ACE score. Cannabis use at delivery was associated with 10% lower birthweight (2665 g vs 3014 g p  
ISSN:1434-1816
1435-1102
DOI:10.1007/s00737-022-01269-x