Reversible ototoxic effect of azithromycin and clarithromycin on transiently evoked otoacoustic emissions in guinea pigs

The possible cochlear toxicity of systemically applied macrolides - erythromycin (ER), azithromycin (AZ) and clarithromycin(CL) - was investigated in guinea pigs by measuring transiently evoked otoacoustic emissions (TEOAEs). A single dose of 125 mg/kg intravenous (i.v.) ER caused no change in TEOAE...

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Bibliographic Details
Published in:Journal of laryngology and otology 2001-08, Vol.115 (8), p.622-628
Main Authors: Uzun, Cem, Koten, Muhsin, Adali, Mustafa Kemal, Yorulmaz, Faruk, Yaǧiz, Recep, Karasalihoglu, Ahmet Rifat
Format: Article
Language:English
Subjects:
(RF) Otorhinolaryngology
Administration, Oral
Adverse
Anesthesia
Animals
Anti-Bacterial Agents - toxicity
Antibiotics
Audiometry
Azithromycin
Azithromycin - toxicity
Biological and medical sciences
Clarithromycin - toxicity
Cochlea
Drug dosages
Drug toxicity and drugs side effects treatment
Ears & hearing
Effects
Erythromycin - toxicity
Guinea Pigs
Hearing loss
Injections, Intravenous
Macrolide
Medical sciences
Otoacoustic Emissions, Spontaneous - drug effects
Pharmacology. Drug treatments
Toxicity
Toxicity: respiratory system, ent, stomatology
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Summary:The possible cochlear toxicity of systemically applied macrolides - erythromycin (ER), azithromycin (AZ) and clarithromycin(CL) - was investigated in guinea pigs by measuring transiently evoked otoacoustic emissions (TEOAEs). A single dose of 125 mg/kg intravenous (i.v.) ER caused no change in TEOAEs in guinea pigs (p>0.05), whereas AZ (45 mg/kg orally) and CL (75 mg/kg i.v.) reversibly reduced the emission response (p
ISSN:0022-2151
1748-5460
DOI:10.1258/0022215011908676