Canine Epidermal Langerhans Cells Express [alpha] and [gamma] but not [beta] Chains of High-Affinity IgE Receptor

Epidermal Langerhans cells (LC) express a high-affinity receptor for IgE (Fc[straight epsilon]RI), consisting of two chains (α and γ chains) in humans that allows LC to perform Fc receptor-mediated uptake of allergens. We found that canine LC express α and γ chains but not β chain of Fc[straight eps...

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Bibliographic Details
Published in:Veterinary research communications 2005-08, Vol.29 (6), p.499
Main Authors: Bonkobara, M, Miyake, F, Yagihara, H, Yamada, O, Azakami, D, Washizu, T, Cruz, P D, Ariizumi, K
Format: Article
Language:English
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Summary:Epidermal Langerhans cells (LC) express a high-affinity receptor for IgE (Fc[straight epsilon]RI), consisting of two chains (α and γ chains) in humans that allows LC to perform Fc receptor-mediated uptake of allergens. We found that canine LC express α and γ chains but not β chain of Fc[straight epsilon]RI, identical to human but not to mouse LC, which do not express functional Fc[straight epsilon]RI (only γ chain is expressed). This finding indicates that canine LC have Fc[straight epsilon]RI-mediated function similar to or identical to human LC, raising the possibility that canine species provides a better model than mouse to understand the pathogenesis of human atopic dermatitis and investigate the therapeutic effect of drugs.
ISSN:0165-7380
1573-7446
DOI:10.1007/s11259-005-2494-7