Identification of genomic signatures and multiple lineage markers from the second and third wave samples of COVID-19 in Western Rajasthan, India

• Published in: bioRxiv 2022-12
• Main Authors: Gadepalli, Ravisekhar, Bokolia, Naveen Prakash
• Format: Article
• Language: English
• Subjects: Coronaviruses; COVID-19; Disease transmission; Genomics; Infectivity; Mortality; Mutation; Severe acute respiratory syndrome coronavirus 2
• DOI: 10.1101/2022.12.10.518819

Most of the mutations occurred in SARS-CoV-2 are either relatively neutral or swiftly purged. However, some mutations have altered the functional aspects in terms of infectivity and transmission, host-viral interactions, disease severity and immune or vaccine escape. There are emerging evidence that certain mutations are jeopardizing the immune based therapies. The present research report is focused on the identification of genomic signatures of SARS-CoV-2 variant that caused mortality during second and third wave of COVID-19 in Western Rajasthan, India. We identified that Delta clade of SARS-CoV-2 is the predominant cause of mortality during second wave and even third wave in Western Rajasthan, India. Importantly, this study also revealed the unique and common substitution mutations within the spike domain, those are present in mortality and survived persons during the second and third wave of COVID-19 in India. In addition, this study also revealed the multiple lineage markers (Delta and Omicron), that would update with insightful understanding in the clade development of SARS-CoV-2.Competing Interest StatementThe authors have declared no competing interest.