One‐Pot Synthesis of Thiocarbamide Esters: Construction of C−S Bonds under Transition‐Metal‐Free Conditions

A convenient and effective method for the construction of C−S bond under transition‐metal free conditions was reported. Thus, diverse thiocarbamide esters could be smoothly obtained in moderate to good yields from inexpensive and readily available starting materials, such as phenyl isothiocyanate, a...

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Bibliographic Details
Published in:European journal of organic chemistry 2022-12, Vol.2022 (46), p.n/a
Main Authors: Deng, Shi‐Hao, Yu, Jun‐Xia, Xiao, Hua‐Qing, Dong, Zhi‐Bing
Format: Article
Language:English
Subjects:
Alcohols
C−S bond
Esters
Halides
One-Pot
Reaction time
Substrates
Synthesis
Thiocarbamide Esters
Thioureas
Transition-Metal free
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Summary:A convenient and effective method for the construction of C−S bond under transition‐metal free conditions was reported. Thus, diverse thiocarbamide esters could be smoothly obtained in moderate to good yields from inexpensive and readily available starting materials, such as phenyl isothiocyanate, alcohols and benzyl halides. This method features mild conditions, easy operation, short reaction time and broad substrate scopes, providing a facile and convenient strategy for the preparation of some compounds with potential biological activities. Under transition‐metal‐free conditions, a series of thiocarbamide esters could be quickly and conveniently obtained by NaOH‐promotion in one pot manner. It's noteworthy that the desired products could be obtained in moderate to excellent yields from inexpensive and easily available starting materials, providing an alternative way to afford various thiocarbamide esters.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202201167