The Structure and Properties of Bioresorbable Polylactide-Based Materials for Regenerative Medicine

This work presents a comparative study on the bioresorption of samples based on natural biopolymers, such as polyhydroxybutyrate, polylactide, polycaprolactone, and chitosan, in living systems and an evaluation of the tissue response to these samples. A histological examination of the polylactide-co...

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Bibliographic Details
Published in:Polymer science. Series D, Glues and sealing materials Glues and sealing materials, 2022, Vol.15 (4), p.734-740
Main Authors: Ol’khov, A. A., Muraev, A. A., Volkov, A. V., Ivashkevich, S. G., Kim, E. V., Pozdnyakov, M. S., Staroverova, O. V., Iordanskii, A. L., Gorshenev, V. N.
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Biopolymers
Chemistry
Chemistry and Materials Science
Chitosan
Comparative studies
Foreign bodies
Granulation
Lymphocytes
Metabolites
Polycaprolactone
Polyhydroxybutyrate
Polylactic acid
Polymer Sciences
Tissue engineering
Veterinary medicine
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Summary:This work presents a comparative study on the bioresorption of samples based on natural biopolymers, such as polyhydroxybutyrate, polylactide, polycaprolactone, and chitosan, in living systems and an evaluation of the tissue response to these samples. A histological examination of the polylactide-containing tissue samples revealed that the material possesses good supporting functions for connective, bone, and granulation tissues and causes no pronounced inflammatory infiltration with lymphocytes, neutrophils, and giants cells of foreign bodies. The resorption of the material proceeds slowly, and metabolites released during the resorption have no negative effect on the reparative osteogenesis. These materials seem to be quite promising in veterinary medicine.
ISSN:1995-4212
1995-4220
DOI:10.1134/S1995421222040487