Curative effect of zinc‐selenium tea on rat's cardiotoxicity induced by long‐term exposure to nonylphenol

• Published in: Environmental toxicology 2023-01, Vol.38 (1), p.101-114
• Main Authors: Zhang, YuJie, Xu, Jie, Liu, Chao, Long, Xianping, Zheng, Mucong, He, Jie, Lin, Fangmei, Yu, Jie
• Format: Article
• Language: English
• Subjects: Animals; Aspartate aminotransferase; Cardiotoxicity; Collagen; Collagen (type I); Collagen (type III); Creatine; Creatine Kinase; Dehydrogenase; Dehydrogenases; Diastole; Enzymes; Fibrosis; Green tea; Heart; Inflammation; Isoenzymes; Kinases; L-Lactate dehydrogenase; Lactate; Lactate dehydrogenase; Lactic acid; mRNA; myocardial enzymes; myocardial fibrosis; Myocardium; Nonylphenol; Rats; Selenium; Selenium - pharmacology; Serum; Tea; Ventricle; Zinc; Zinc - pharmacology; zinc‐selenium tea
• ISSN: 1520-4081; 1522-7278
• DOI: 10.1002/tox.23667

This study aimed to explore whether zinc‐selenium tea has an curative effect on the cardiotoxicity induced by nonylphenol (NP), and to compare the effect of zinc‐selenium tea and green tea. After drinking of zinc‐selenium tea or green tea, compared with the control group, the left ventricular anterior wall became thinner, and the left ventricular end‐diastolic diameter increased, the anterior wall of the left ventricle became thin at the end of diastole in the NP group. The serum myocardial enzymes aspartate aminotransferase, creatine kinase, creatine kinase isoenzyme, lactate dehydrogenase, and α‐hydroxybutyrate dehydrogenase in the NP group were significantly increased, and the serum myocardial enzymes were significantly decreased after the intervention of zinc‐selenium tea. Proteins and mRNA expressions of Collagen I and Collagen III in the tea groups were lower than those in the NP group. In the green tea and zinc‐selenium tea intervention groups, the disorder and degree of myocardial fiber were alleviated to varying degrees. The disturbance, breakage, and inflammatory cell infiltration of myocardial fibers in zinc‐selenium tea and green tea groups were less than that of NP group. After tea intervention, collagen I and collagen III in the myocardium decreased. The intervention effect of zinc‐selenium tea was better than that of green tea. Zinc‐selenium tea and green tea could interfere with the cardiotoxicity indued by NP, which would alleviate the myocardial fibrosis by reducing expressions of collagen I and collagen III. Moreover, the curative effect of zinc‐selenium tea was better than that of green tea.