Ameliorative Effect of Bouea macrophylla Griffth Seed Extract Against Bacteria-Induced Acne Inflammation: in vitro study

Currently, bioactive compounds derived from nature have been thought to be promising anti-acne substances owing to the variety of potential biological effects. This study aimed to evaluate the ameliorative effect of Bouea macrophylla Griffth seed extract against bacteria-induced acne inflammation fo...

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Bibliographic Details
Published in:Journal of Oleo Science 2022, Vol.71(10), pp.1521-1530
Main Authors: Poomanee, Worrapan, Leelapornpisid, Warat, Trakoolpua, Khajornsak, Salamon, Ivan, Leelapornpisid, Pimporn
Format: Article
Language:English
Subjects:
Acne
acne inflammation
anti-inflammation
antibacterial effect
Antioxidants
antioxidation
Bacteria
Biological effects
Cosmeceuticals
Ethyl acetate
Flavonoids
Inflammation
Lipid peroxidation
Lipids
maprang
Nitric oxide
Scavenging
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Summary:Currently, bioactive compounds derived from nature have been thought to be promising anti-acne substances owing to the variety of potential biological effects. This study aimed to evaluate the ameliorative effect of Bouea macrophylla Griffth seed extract against bacteria-induced acne inflammation for the first time in terms of antibacterial effects against acne-inducing bacteria, anti-inflammatory, and antioxidant properties. Initially, extracting procedures were optimized and five different extracts were obtained. Considering their antibacterial activities against Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, ethanolic and ethyl acetate fractions exerted a notable effect which were highly superior above those of polyphenol standards. Additionally, these two extracts presented outstanding antioxidant capacities in terms of DPPH and ABTS radicals scavenging effects, reducing power, and inhibitory effect on lipid peroxidation which also play a role in the exacerbation of acne inflammation. Besides, inhibition on lipid peroxidation and reducing power of ethanolic fraction were significantly (p
ISSN:1345-8957
1347-3352
DOI:10.5650/jos.ess22168