Controlled Synthesis of Polymer Matrices Based on N-Vinyl Succinimide and N-Vinylpyrrolidone for Immobilization of Low Molecular Weight Active Pharmaceutical Ingredients

The molecular weight characteristics and physicochemical properties of poly- N -vinyl succinimide synthesized under conditions of reversible addition–fragmentation chain transfer mechanism at different concentrations of the chain transfer agent, dibenzyl trithiocarbonate, were determined. The possib...

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Bibliographic Details
Published in:Russian journal of applied chemistry 2022-06, Vol.95 (6), p.836-848
Main Authors: Gostev, A. I., Sivtsov, E. V., Grigor’ev, D. V., Sitnikova, V. E., Tikhomirov, V. M.
Format: Article
Language:English
Subjects:
Block copolymers
Chain transfer
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Copolymers
Immobilization
Industrial Chemistry/Chemical Engineering
Low molecular weights
Macromolecular Compounds and Polymeric Materials
Water chemistry
Water soluble polymers
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Summary:The molecular weight characteristics and physicochemical properties of poly- N -vinyl succinimide synthesized under conditions of reversible addition–fragmentation chain transfer mechanism at different concentrations of the chain transfer agent, dibenzyl trithiocarbonate, were determined. The possibilities of N -vinyl succinimide and N -vinylpyrrolidone copolymers with specified molecular weight characteristics of block and gradient microstructures synthesis are considered A method is shown for producing water-soluble polymer matrices based on copolymers of N -vinylsuccinamic acid and N -vinylpyrrolidone, intended for immobilization of low molecular weight compounds exhibiting bioactive properties. Oil-soluble rimantadine and trimecaine were converted into a water-soluble form by interaction with the produced copolymer.
ISSN:1070-4272
1608-3296
DOI:10.1134/S1070427222060088