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Correlation analysis of triglycerides to high-density lipoprotein-cholesterol ratio associated with gestational diabetes mellitus
Background Gestational diabetes mellitus (GDM) initiates when a woman’s pancreas could not act appropriately to bypass the diabetogenic condition during pregnancy. It is increasing across the world, including Bangladesh. Triglycerides (TG) and high-density lipoprotein-cholesterol (HDLC) are strongly...
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| Published in: | International journal of diabetes in developing countries 2022-10, Vol.42 (4), p.636-641 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 641 |
| container_issue | 4 |
| container_start_page | 636 |
| container_title | International journal of diabetes in developing countries |
| container_volume | 42 |
| creator | Obaidullah, Md. Mim Islam, Shirmin Chowdhury, Md. Rayhan Arbia, Lubatul Hossain, Israt Ara Matin, Mohammad Nurul |
| description | Background
Gestational diabetes mellitus (GDM) initiates when a woman’s pancreas could not act appropriately to bypass the diabetogenic condition during pregnancy. It is increasing across the world, including Bangladesh. Triglycerides (TG) and high-density lipoprotein-cholesterol (HDLC) are strongly connected with insulin resistance in pregnant women.
Objectives
Observation of the role of lipid profiles and TG/HDL cholesterol ratio associated with fasting glucose in GDM subjects.
Methods
In this experiment, a total of 232 individual subjects consisting of 132 GDM-positive and 100 GDM-negative pregnant women were examined and observed from 24 to 28 weeks of their pregnancy period. For this study, we had collected blood samples from selected women before and after breakfast and analyzed blood glucose level, triglyceride cholesterol level, HDL, low-density lipoprotein (LDL), and TG/HDL ratio.
Results
TG and LDL-cholesterol were significantly higher (
p
|
| doi_str_mv | 10.1007/s13410-021-01016-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2755891323</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2755891323</sourcerecordid><originalsourceid>FETCH-LOGICAL-c270t-4a094391cacd0ba49624353027f3d5fd9bb564baf60f49a3a48589e1901df8753</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EEqXwB5gsMRvOdpzEI6r4kpBYYLacxElduXGxXaGM_HPcBomN6YZ777lXD0LXFG4pQHUXKS8oEGCUAAVaEnGCFlTKmvCas1O0AFlxwiWHc3QR4wZACFbyBfpe-RCM08n6EetRuynaiH2PU7CDm1oTbGciTh6v7bAmnRmjTRN2dud3wSdjR9KuvTMxmeAdDgcQ1jH61upkOvxl0xoPeX38oB3urG5Mysitcc6mfbxEZ7120Vz9ziX6eHx4Xz2T17enl9X9K2lZBYkUGmTBJW1120GjC1myggsOrOp5J_pONo0oi0b3JfSF1FwXtailoRJo19eV4Et0M3Nz7899bqQ2fh9ypahYJXKWcsZzis2pNvgYg-nVLtitDpOioA6q1axaZdXqqFod0Hw-ijk8Dib8of-5-gECC4TI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2755891323</pqid></control><display><type>article</type><title>Correlation analysis of triglycerides to high-density lipoprotein-cholesterol ratio associated with gestational diabetes mellitus</title><source>Springer Nature</source><creator>Obaidullah, Md. Mim ; Islam, Shirmin ; Chowdhury, Md. Rayhan ; Arbia, Lubatul ; Hossain, Israt Ara ; Matin, Mohammad Nurul</creator><creatorcontrib>Obaidullah, Md. Mim ; Islam, Shirmin ; Chowdhury, Md. Rayhan ; Arbia, Lubatul ; Hossain, Israt Ara ; Matin, Mohammad Nurul</creatorcontrib><description>Background
Gestational diabetes mellitus (GDM) initiates when a woman’s pancreas could not act appropriately to bypass the diabetogenic condition during pregnancy. It is increasing across the world, including Bangladesh. Triglycerides (TG) and high-density lipoprotein-cholesterol (HDLC) are strongly connected with insulin resistance in pregnant women.
Objectives
Observation of the role of lipid profiles and TG/HDL cholesterol ratio associated with fasting glucose in GDM subjects.
Methods
In this experiment, a total of 232 individual subjects consisting of 132 GDM-positive and 100 GDM-negative pregnant women were examined and observed from 24 to 28 weeks of their pregnancy period. For this study, we had collected blood samples from selected women before and after breakfast and analyzed blood glucose level, triglyceride cholesterol level, HDL, low-density lipoprotein (LDL), and TG/HDL ratio.
Results
TG and LDL-cholesterol were significantly higher (
p
< 0.001) in GDM individuals (220.95 ± 67.4 and 149.54 ± 32.4, respectively) than those of the non-GDM (160.98 ± 59.67 and 129.18 ± 34.18, respectively). On the contrary, HDL-cholesterol level was comparatively lower in GDM-positive women than non-GDM subjects. In this case, the optimum cut-off point was 3.8 for the TG/HDL-C ratio with 62% sensitivity and 78% specificity by oral glucose tolerance test (OGTT).
Conclusion
Significantly (
p
< 0.001) higher TG/HDL ratio was found in GDM women compared with those in non‐GDM. TG/HDL ratios are independently associated with the risks of GDM, which might be a good marker in predicting GDM risk.</description><identifier>ISSN: 0973-3930</identifier><identifier>EISSN: 1998-3832</identifier><identifier>DOI: 10.1007/s13410-021-01016-5</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Blood glucose ; Cholesterol ; Correlation analysis ; Diabetes ; Diabetes mellitus ; Family Medicine ; General Practice ; Gestational diabetes ; Glucose ; Glucose tolerance ; Health Administration ; High density lipoprotein ; Insulin ; Insulin resistance ; Lipoproteins ; Low density lipoprotein ; Medicine ; Medicine & Public Health ; Original Article ; Pregnancy ; Pregnancy complications ; Triglycerides</subject><ispartof>International journal of diabetes in developing countries, 2022-10, Vol.42 (4), p.636-641</ispartof><rights>Research Society for Study of Diabetes in India 2021</rights><rights>Research Society for Study of Diabetes in India 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-4a094391cacd0ba49624353027f3d5fd9bb564baf60f49a3a48589e1901df8753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Obaidullah, Md. Mim</creatorcontrib><creatorcontrib>Islam, Shirmin</creatorcontrib><creatorcontrib>Chowdhury, Md. Rayhan</creatorcontrib><creatorcontrib>Arbia, Lubatul</creatorcontrib><creatorcontrib>Hossain, Israt Ara</creatorcontrib><creatorcontrib>Matin, Mohammad Nurul</creatorcontrib><title>Correlation analysis of triglycerides to high-density lipoprotein-cholesterol ratio associated with gestational diabetes mellitus</title><title>International journal of diabetes in developing countries</title><addtitle>Int J Diabetes Dev Ctries</addtitle><description>Background
Gestational diabetes mellitus (GDM) initiates when a woman’s pancreas could not act appropriately to bypass the diabetogenic condition during pregnancy. It is increasing across the world, including Bangladesh. Triglycerides (TG) and high-density lipoprotein-cholesterol (HDLC) are strongly connected with insulin resistance in pregnant women.
Objectives
Observation of the role of lipid profiles and TG/HDL cholesterol ratio associated with fasting glucose in GDM subjects.
Methods
In this experiment, a total of 232 individual subjects consisting of 132 GDM-positive and 100 GDM-negative pregnant women were examined and observed from 24 to 28 weeks of their pregnancy period. For this study, we had collected blood samples from selected women before and after breakfast and analyzed blood glucose level, triglyceride cholesterol level, HDL, low-density lipoprotein (LDL), and TG/HDL ratio.
Results
TG and LDL-cholesterol were significantly higher (
p
< 0.001) in GDM individuals (220.95 ± 67.4 and 149.54 ± 32.4, respectively) than those of the non-GDM (160.98 ± 59.67 and 129.18 ± 34.18, respectively). On the contrary, HDL-cholesterol level was comparatively lower in GDM-positive women than non-GDM subjects. In this case, the optimum cut-off point was 3.8 for the TG/HDL-C ratio with 62% sensitivity and 78% specificity by oral glucose tolerance test (OGTT).
Conclusion
Significantly (
p
< 0.001) higher TG/HDL ratio was found in GDM women compared with those in non‐GDM. TG/HDL ratios are independently associated with the risks of GDM, which might be a good marker in predicting GDM risk.</description><subject>Blood glucose</subject><subject>Cholesterol</subject><subject>Correlation analysis</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Family Medicine</subject><subject>General Practice</subject><subject>Gestational diabetes</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Health Administration</subject><subject>High density lipoprotein</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Lipoproteins</subject><subject>Low density lipoprotein</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Triglycerides</subject><issn>0973-3930</issn><issn>1998-3832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EEqXwB5gsMRvOdpzEI6r4kpBYYLacxElduXGxXaGM_HPcBomN6YZ777lXD0LXFG4pQHUXKS8oEGCUAAVaEnGCFlTKmvCas1O0AFlxwiWHc3QR4wZACFbyBfpe-RCM08n6EetRuynaiH2PU7CDm1oTbGciTh6v7bAmnRmjTRN2dud3wSdjR9KuvTMxmeAdDgcQ1jH61upkOvxl0xoPeX38oB3urG5Mysitcc6mfbxEZ7120Vz9ziX6eHx4Xz2T17enl9X9K2lZBYkUGmTBJW1120GjC1myggsOrOp5J_pONo0oi0b3JfSF1FwXtailoRJo19eV4Et0M3Nz7899bqQ2fh9ypahYJXKWcsZzis2pNvgYg-nVLtitDpOioA6q1axaZdXqqFod0Hw-ijk8Dib8of-5-gECC4TI</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Obaidullah, Md. Mim</creator><creator>Islam, Shirmin</creator><creator>Chowdhury, Md. Rayhan</creator><creator>Arbia, Lubatul</creator><creator>Hossain, Israt Ara</creator><creator>Matin, Mohammad Nurul</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20221001</creationdate><title>Correlation analysis of triglycerides to high-density lipoprotein-cholesterol ratio associated with gestational diabetes mellitus</title><author>Obaidullah, Md. Mim ; Islam, Shirmin ; Chowdhury, Md. Rayhan ; Arbia, Lubatul ; Hossain, Israt Ara ; Matin, Mohammad Nurul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-4a094391cacd0ba49624353027f3d5fd9bb564baf60f49a3a48589e1901df8753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Blood glucose</topic><topic>Cholesterol</topic><topic>Correlation analysis</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Family Medicine</topic><topic>General Practice</topic><topic>Gestational diabetes</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Health Administration</topic><topic>High density lipoprotein</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Lipoproteins</topic><topic>Low density lipoprotein</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obaidullah, Md. Mim</creatorcontrib><creatorcontrib>Islam, Shirmin</creatorcontrib><creatorcontrib>Chowdhury, Md. Rayhan</creatorcontrib><creatorcontrib>Arbia, Lubatul</creatorcontrib><creatorcontrib>Hossain, Israt Ara</creatorcontrib><creatorcontrib>Matin, Mohammad Nurul</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>International journal of diabetes in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obaidullah, Md. Mim</au><au>Islam, Shirmin</au><au>Chowdhury, Md. Rayhan</au><au>Arbia, Lubatul</au><au>Hossain, Israt Ara</au><au>Matin, Mohammad Nurul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation analysis of triglycerides to high-density lipoprotein-cholesterol ratio associated with gestational diabetes mellitus</atitle><jtitle>International journal of diabetes in developing countries</jtitle><stitle>Int J Diabetes Dev Ctries</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>42</volume><issue>4</issue><spage>636</spage><epage>641</epage><pages>636-641</pages><issn>0973-3930</issn><eissn>1998-3832</eissn><abstract>Background
Gestational diabetes mellitus (GDM) initiates when a woman’s pancreas could not act appropriately to bypass the diabetogenic condition during pregnancy. It is increasing across the world, including Bangladesh. Triglycerides (TG) and high-density lipoprotein-cholesterol (HDLC) are strongly connected with insulin resistance in pregnant women.
Objectives
Observation of the role of lipid profiles and TG/HDL cholesterol ratio associated with fasting glucose in GDM subjects.
Methods
In this experiment, a total of 232 individual subjects consisting of 132 GDM-positive and 100 GDM-negative pregnant women were examined and observed from 24 to 28 weeks of their pregnancy period. For this study, we had collected blood samples from selected women before and after breakfast and analyzed blood glucose level, triglyceride cholesterol level, HDL, low-density lipoprotein (LDL), and TG/HDL ratio.
Results
TG and LDL-cholesterol were significantly higher (
p
< 0.001) in GDM individuals (220.95 ± 67.4 and 149.54 ± 32.4, respectively) than those of the non-GDM (160.98 ± 59.67 and 129.18 ± 34.18, respectively). On the contrary, HDL-cholesterol level was comparatively lower in GDM-positive women than non-GDM subjects. In this case, the optimum cut-off point was 3.8 for the TG/HDL-C ratio with 62% sensitivity and 78% specificity by oral glucose tolerance test (OGTT).
Conclusion
Significantly (
p
< 0.001) higher TG/HDL ratio was found in GDM women compared with those in non‐GDM. TG/HDL ratios are independently associated with the risks of GDM, which might be a good marker in predicting GDM risk.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s13410-021-01016-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0973-3930 |
| ispartof | International journal of diabetes in developing countries, 2022-10, Vol.42 (4), p.636-641 |
| issn | 0973-3930 1998-3832 |
| language | eng |
| recordid | cdi_proquest_journals_2755891323 |
| source | Springer Nature |
| subjects | Blood glucose Cholesterol Correlation analysis Diabetes Diabetes mellitus Family Medicine General Practice Gestational diabetes Glucose Glucose tolerance Health Administration High density lipoprotein Insulin Insulin resistance Lipoproteins Low density lipoprotein Medicine Medicine & Public Health Original Article Pregnancy Pregnancy complications Triglycerides |
| title | Correlation analysis of triglycerides to high-density lipoprotein-cholesterol ratio associated with gestational diabetes mellitus |
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