Detection of Matrix Metalloproteinases in the Heart of Preterm Rats

The influence of preterm birth on the expression of matrix metalloproteinases (MMP2 and MMP9) in the wall of the left ventricle of the rat heart in the early postnatal period of ontogenesis (up to 21 days) was studied. The hearts of preterm (gestation duration 21 and 21.5 days) and term (gestation d...

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Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences 2022-12, Vol.49 (6), p.671-676
Main Authors: Ivanova, V. V., Milto, I. V., Serebryakova, O. N., Sukhodolo, I. V.
Format: Article
Language:English
Subjects:
Animal and Human Physiology
Biochemistry
Biomedical and Life Sciences
Cell Biology
Ecology
Gelatinase A
Gelatinase B
Gestation
Heart
Life Sciences
Matrix metalloproteinase
Premature birth
Ventricle
Zoology
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Summary:The influence of preterm birth on the expression of matrix metalloproteinases (MMP2 and MMP9) in the wall of the left ventricle of the rat heart in the early postnatal period of ontogenesis (up to 21 days) was studied. The hearts of preterm (gestation duration 21 and 21.5 days) and term (gestation duration 22 days) Wistar rats on days 7 and 21 of the postnatal period of ontogenesis were studied immunohistochemically in the experiment. Preterm birth has no effect on the pattern of immunohistochemical staining of MMP2 in the wall of the left ventricle of rats, while the content of MMP9 decreases by day 7 and increases by day 21 of the postnatal period of ontogenesis, compared with that of term rats.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359022060073