Conductive and antibacterial scaffold with rapid crimping property for application prospect in repair of peripheral nerve injury

Peripheral nerve injury (PNI) is a severe clinical disease leading to the loss of sensory and motor function and even lifelong disability of patients. Nerve scaffolds with conductive materials are beneficial to PNI repair and regeneration through the recovery of electrical signals transmission and r...

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Bibliographic Details
Published in:Journal of applied polymer science 2023-02, Vol.140 (5), p.n/a
Main Authors: Zhang, Hai‐qiang, Lan, Dong‐wei, Li, Xia, Li, Zhi, Dai, Fang‐Yin
Format: Article
Language:English
Subjects:
antibacterial
Biocompatibility
Cell membranes
conductive
Electrical raceways
Electrospinning
Ethanol
Folding
Human motion
Materials science
Membranes
peripheral nerve repair
Peripheral nerves
Polymers
rapid crimping
Regeneration
Scaffolds
Surgical implants
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Summary:Peripheral nerve injury (PNI) is a severe clinical disease leading to the loss of sensory and motor function and even lifelong disability of patients. Nerve scaffolds with conductive materials are beneficial to PNI repair and regeneration through the recovery of electrical signals transmission and regulation of nerve cell membrane function. In this study, composite poly(lactide‐co‐glycolide) (PLGA)/Ti3C2Tx (MXene) membranes with different content of MXene were fabricated by electrospinning, and these fibrous membranes showed favorable mechanical property for supporting nerve regeneration. With loaded MXene, the electrospun membranes exhibited good antibacterial property that the antimicrobial rate was as high as 80%, which is conducive to the prevention of wound inflammation after stent implantation. The loaded MXene also improved the hydrophilicity and conductivity of the electrospun composite membranes, which provided good biocompatibility for cell growth. Interestingly, treating in 75% ethanol solution made fabricated PLGA/MXene membranes rapidly crimp into stable nerve conduits for implanted application. These fabricated PLGA/MXene membranes showed good potential for nerve repair and have a good prospect for nerve conduit application. Schematic of PLGA/MXene membranes preparation and application.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.53426