Comparative pathogenesis of two genotype VI.2 avian paramyxovirus type-1 viruses (APMV-1) in pheasants, partridges and chickens

• Published in: Avian pathology 2023-02, Vol.52 (1), p.36-50
• Main Authors: Ross, Craig S., Sutton, David, Skinner, Paul, Mahmood, Sahar, Wynne, Felicity, Londt, Brandon, Fuller, Chad M., Mayers, Jo, Nunez, Alejandro, Hicks, Daniel J., Brookes, Sharon M., Banyard, Ashley C., Brown, Ian H.
• Format: Article
• Language: English
• Subjects: Animals; Asymptomatic; Birds; Chickens; Diseases; Dynamics; Economic importance; Epidemiology; game birds; Games; Genotype; Genotype & phenotype; Genotypes; Infections; Newcastle Disease; Newcastle disease virus; Pathogenesis; pathogenicity; Phylogeny; Pigeon paramyxovirus-1; Pigeons; Poultry; Quail; Seroconversion; transmission; Viruses; Wildfowl
• ISSN: 0307-9457; 1465-3338
• DOI: 10.1080/03079457.2022.2133680

Newcastle disease (ND) is caused by virulent forms of avian paramyxovirus-1 (APMV-1) and is an economically important disease of poultry world-wide. Pigeon paramyxovirus 1 (PPMV-1), a sub-group of APMV-1 is endemic in Columbiformes and can cause infections of poultry. An outbreak of ND in partridges in Scotland, UK, in 2006 (APMV-1/partridge/UK(Scotland)/7575/06) was identified as a class II, genotype VI.2.1.1.2.1, more commonly associated with PPMV-1. It has been hypothesized that game birds may be a route of transmission into commercial poultry settings due to the semi-feral rearing system, which potentially brings them into contact with both wild-birds and poultry species. Therefore, the pathogenesis and transmission of APMV-1/partridge/UK(Scotland)/7575/06 in game birds and chickens was investigated, and compared to a contemporary PPMV-1 isolate, PPMV-1/pigeon/UK/015874/15. Viral shedding and seroconversion profiles demonstrated that pheasants were susceptible to infection with APMV-1/partridge/UK(Scotland)/7575/06 with limited clinical signs observed although they were able to excrete and transmit virus. In contrast, partridges and pheasants showed limited infection with PPMV-1/pigeon/UK/015874/15, causing mild clinical disease. Chickens, however, were productively infected and were able to transmit virus in the absence of clinical signs. From the data, it can be deduced that whilst game birds may play a role in the transmission and epidemiology of genotype VI.2 APMV-1 viruses, the asymptomatic nature of circulation within these species precludes evaluation of natural infection by clinical surveillance. It therefore remains a possibility that genotype VI.2 APMV-1 infection in game birds has the potential for asymptomatic circulation and remains a potential threat to avian production systems. RESEARCH HIGHLIGHTS Demonstration of infection of game birds with Pigeon paramyxovirus-1 (PPMV-1). There are differing dynamics of infection between different game bird species. Differing dynamics of infection between different PPMV-1 isolates and genotypes in game birds and chickens.