PP66 Safety, Effectiveness And Cost-effectiveness Of Scalp Cooling Devices For The Prevention Of Chemotherapy-induced Alopecia

IntroductionChemotherapy-induced alopecia (CIA), although reversible, is one of the most common and distressing side effects of cancer therapy, affecting approximately 65 percent of all patients and influencing treatment decisions in some of them. Scalp cooling (SC) is a method aiming to prevent CIA...

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Published in:International journal of technology assessment in health care 2022-12, Vol.38 (S1), p.S61-S62
Main Authors: Infante-Ventura, Diego, de Armas-Castellano, Aythami, Hernández-Yumar, Aránzazu, González-Pacheco, Himar, Pino-Sedeño, Tasmania del, González-Hernández, Yadira, García-Pérez, Lidia, Ramallo-Fariña, Yolanda, Rodríguez-Rodríguez, Leticia, Rueda-Domínguez, Antonio, Serrano-Aguilar, Pedro, del Mar Trujillo-Martín, María
Format: Article
Language:English
Subjects:
Alopecia
Anthracycline
Baldness
Breast cancer
Cancer therapies
Chemotherapy
Clinical trials
Cost analysis
Devices
Economic analysis
Economics
Effectiveness
Meta-analysis
Patients
Poster Presentations
Prevention
Safety
Scalp
Side effects
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Summary:IntroductionChemotherapy-induced alopecia (CIA), although reversible, is one of the most common and distressing side effects of cancer therapy, affecting approximately 65 percent of all patients and influencing treatment decisions in some of them. Scalp cooling (SC) is a method aiming to prevent CIA. Our study aims to evaluate the real value of SC devices.MethodsA systematic review of the available scientific literature on the safety, effectiveness and cost-effectiveness of the use of SC compared with no intervention was performed. Overall effect size was estimated through a meta-analysis. An economic analysis in the Spanish context from the Spanish National Healthcare System (NHS) and social perspectives was performed.ResultsThirteen randomized controlled trials (n = 832) were included but only nine contributed to the meta-analysis. A large effect in favor of SC reducing hair loss was found (RR=0.57; 95% CI: 0.46-0.69). No differences were observed according to the type of cancer, although there was a small positive effect for breast cancer. A higher effect was found in patients treated with a combination anthracyclines/taxanes treatment compared to those treated only with anthracyclines. The only economic evaluation found in the literature was conducted in The Netherlands and concluded that Paxman system was less costly than usual care from societal perspective and no differences in quality adjusted life years (QALYs) were observed. The de novo economic analysis showed that the strategies including SC devices generated more costs and QALYs (given some assumed utility values) than usual care (not SC), presenting incremental cost-effectiveness ratios below the threshold calculated for Spain (EUR 25,000 /QALY), from both perspectives.ConclusionsThe results suggest that SC are effective for the prevention of CIA. Furthermore, assuming the utility values used in the model, SC devices are cost-effective compared to usual care (not SC).
ISSN:0266-4623
1471-6348
DOI:10.1017/S0266462322001994