Synthesis of a C3 Hydroxyproline-modified Carbapenem

Methyl (4 R )-4-hydroxy-1-(sulfanylacetyl)-l-prolinate was synthesized starting from trans -4-l-hydroxyprolinate methyl ester hydrochloride and then reacted with the known carbapenem enol phosphate to obtain the corresponding carbapenem and then to chemically more stable methyl ester.

Saved in:
Bibliographic Details
Published in:Russian journal of organic chemistry 2022-11, Vol.58 (11), p.1664-1667
Main Authors: Valiullina, Z. R., Galeeva, A. M., Miftakhov, M. S.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Methyl (4 R )-4-hydroxy-1-(sulfanylacetyl)-l-prolinate was synthesized starting from trans -4-l-hydroxyprolinate methyl ester hydrochloride and then reacted with the known carbapenem enol phosphate to obtain the corresponding carbapenem and then to chemically more stable methyl ester.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428022110173