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Role of Surfactant and Co-surfactant in Microemulsion: A Review

Microemulsions are one in all the most effective candidates as novel drug delivery system due to their long time period stability, improved drug solubilization with simple preparation and administration. Surfactants and cosurfactants play crucial role to get stable, mild and clinically acceptable mi...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2022-10, Vol.15 (10), p.4829-4834
Main Authors: Ande, Sagar N, Sonone, Krutika B, Bakal, Ravindrakumar L, Ajmire, Prashant V, Sawarkar, Harigopal S
Format: Article
Language:English
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Summary:Microemulsions are one in all the most effective candidates as novel drug delivery system due to their long time period stability, improved drug solubilization with simple preparation and administration. Surfactants and cosurfactants play crucial role to get stable, mild and clinically acceptable microemulsions in their optimized concentration, The main aim of the study to produce an efficient screening approach for the surfactant and cosurfactant selection for the excipients of microemulsion formulation development and to check the consequences of surfactant hydrophilic–lipophilic balance (HLB) as well solubilization stability process in microemulsion. The composition and extent of surfactants and cosurfactants were key variables for physicochemical properties of drug-loaded Microemulsions. The important aspects must be considered for a successful microemulsion process is that the stability of the liquid membrane. This study is an attempt to grasp the mechanism of the effect of the surfactant and chain length of co-surfactants within the microemulsion base formulation stability.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2022.00811