Therapeutic potential of antimicrobial peptides for treatment of wound infection

Healing of cutaneous wounds is a fundamental process required to re-establish tissue integrity, repair skin barrier function, and restore skin homeostasis. Chronic wound infection, exacerbated by the growing development of resistance to conventional therapies, hinders the skin repair process and is...

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Published in:American Journal of Physiology: Cell Physiology 2023-01, Vol.324 (1), p.C29-C38
Main Authors: Haidari, Hanif, Melguizo-Rodríguez, Lucía, Cowin, Allison J, Kopecki, Zlatko
Format: Article
Language:English
Subjects:
Antimicrobial agents
Antimicrobial peptides
Antimicrobial Peptides - therapeutic use
Chronic infection
Clinical trials
Environmental factors
Homeostasis
Humans
Immune response
Peptides
Photolysis
Proteolysis
Recovery of function
Skin
Wound healing
Wound infection
Wound Infection - drug therapy
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Summary:Healing of cutaneous wounds is a fundamental process required to re-establish tissue integrity, repair skin barrier function, and restore skin homeostasis. Chronic wound infection, exacerbated by the growing development of resistance to conventional therapies, hinders the skin repair process and is a serious clinical problem affecting millions of people worldwide. In the past decade, the use of antimicrobial peptides (AMPs) has attracted increasing attention as a potential novel strategy for the treatment of chronic wound infections due to their unique multifaceted mechanisms of action, and AMPs have been demonstrated to function as potent host-defense molecules that can control microbial proliferation, modulate host-immune responses, and act as endogenous mediators of wound healing. To date over 3,200 AMPs have been discovered either from living organisms or through synthetic derivation, some of which have progressed to clinical trials for the treatment of burn and wound injuries. However, progress to routine clinical use has been hindered due to AMPs' susceptibility to wound and environmental factors including changes in pH, proteolysis, hydrolysis, oxidation, and photolysis. This review will discuss the latest research focused on the development and applications of AMPs for wound infections using the latest nanotechnological approaches to improve AMP delivery, and stability to present effective combinatorial treatment for clinical applications.
ISSN:0363-6143
1522-1563
DOI:10.1152/ajpcell.00080.2022