Schiff bases compounds prepared from Phenyl hydrazine as a starting material were Synthesized, Characterized, and their Biological activity was Investigated

Preparation of Schiff bases compounds (A, B, and C) in absolute ethanol using concentrated phenyl hydrazine and various aromatic aldehydes such as (4-chlrobenzaldehyde aldehyde, 4-bromobenzaldehyde, N, N-dimethyl amino benzaldehyde). Melting point, FT, has been used to classify these compounds (A, B...

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Published in:Research journal of pharmacy and technology 2022-08, Vol.15 (8), p.3595-3598
Main Authors: Salman Salih, Nuha, Ibrahem Yahya, Widad, Yousif Al-Labban, Hutham Mahmood, Jaloob Aljanaby, Ahmed Abduljabbar
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
Biological activity
Ethanol
Infections
Pharmacodynamics
Pharmacology
Pharmacy
Urogenital system
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Summary:Preparation of Schiff bases compounds (A, B, and C) in absolute ethanol using concentrated phenyl hydrazine and various aromatic aldehydes such as (4-chlrobenzaldehyde aldehyde, 4-bromobenzaldehyde, N, N-dimethyl amino benzaldehyde). Melting point, FT, has been used to classify these compounds (A, B, and C). The reactions phases and series were studied using IR spectroscopy and thin layer chromatography (TLC) (ethyl acetate: toluene, 1:4). Three derivate compounds were used as antibacterial activity in this study. The results proved that all derivative compounds provided good inhibition zone against Staphylococcus aureus and pseudomonas aeruginosa especially in concentration 300mg/ml of derivative compound C with diameter inhibition zone 21.433±0.676 and 625.33±0.796 respectively.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2022.00602