Condyloma and coincidental epidermodysplasia verruciformis acanthoma positive for human papillomavirus‐14 and ‐21

Epidermodysplasia verruciformis (EDV) is a rare genodermatosis that predisposes individuals to persistent infection with β‐human papillomavirus (HPV) genotypes. The term EDV acanthoma may be applied to lesions with incidental findings of EDV‐defining histopathological features without clinical signs...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cutaneous pathology 2023-01, Vol.50 (1), p.47-50
Main Authors: Bartley, Brooke, Cho, Woo Cheal, Rady, Peter L., Dai, Julia, Curry, Jonathan L., Milbourne, Andrea, Tyring, Stephen K., Torres‐Cabala, Carlos A.
Format: Article
Language:English
Subjects:
acanthoma
Acanthoma - complications
Biopsy
Case reports
Cervix
Coexistence
condyloma
Condylomata Acuminata - complications
Epidermodysplasia verruciformis
Epidermodysplasia Verruciformis - complications
Epidermodysplasia Verruciformis - pathology
Female
Genodermatosis
Genotypes
Human papillomavirus
Human Papillomavirus Viruses
human papillomavirus‐14 and ‐21
Humans
immunocompromised host
Immunosuppressive agents
Kidney diseases
Lesions
Mycophenolate mofetil
Mycophenolic acid
Papillomaviridae
Papillomavirus Infections - pathology
Prednisone
Skin Neoplasms - complications
squamous cell carcinoma
Systemic lupus erythematosus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epidermodysplasia verruciformis (EDV) is a rare genodermatosis that predisposes individuals to persistent infection with β‐human papillomavirus (HPV) genotypes. The term EDV acanthoma may be applied to lesions with incidental findings of EDV‐defining histopathological features without clinical signs of EDV. We report a case of HPV‐14‐ and ‐21‐positive EDV acanthoma arising in association with condyloma in a female patient with a history of low‐grade squamous intraepithelial lesion of the cervix positive for high‐risk HPV (non‐16/18), chronic kidney disease, and systemic lupus erythematosus. The patient had no family or personal history of EDV, but the patient was on immunosuppressive therapy with mycophenolate mofetil and prednisone. A biopsy specimen from one of the perianal lesions revealed histopathologic changes consistent with EDV in the setting of condyloma. Molecular testing showed HPV‐14 and ‐21, which supported the coexistence of condyloma with EDV acanthoma.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14319