Antibacterial and cellular behavior of PLA-based bacitracin and zataria multiflora nanofibers produced by electrospinning method

In this study, poly(lactic-acid) (PLA) polymer-based nanofiber (NF) was obtained by the electrospinning method. Antioxidant Zataria Multiflora (ZM, essential oil extract) and antibiotic effective bacitracin (BAC) materials were added to 8% PLA. ZM essential oil was extracted with Rotary and antioxid...

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Bibliographic Details
Published in:International journal of polymeric materials 2023-03, Vol.72 (4), p.319-334
Main Authors: Ciftci, Fatih, Duygulu, Nilüfer, Yilmazer, Yasemin, Karavelioğlu, Zeynep, Çakır Koç, Rabia, Gündüz, Oguzhan, Ustündag, Cem Bülent
Format: Article
Language:English
Subjects:
Adhesion
Antibiotics
Antiinfectives and antibacterials
Antioxidant
Antioxidants
carvacrol
drug
E coli
electrospinning
essential oil
Essential oils
Microorganisms
Nanofibers
polymer nanofiber
Thymol
Toxicity
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Summary:In this study, poly(lactic-acid) (PLA) polymer-based nanofiber (NF) was obtained by the electrospinning method. Antioxidant Zataria Multiflora (ZM, essential oil extract) and antibiotic effective bacitracin (BAC) materials were added to 8% PLA. ZM essential oil was extracted with Rotary and antioxidant components were investigated using GC-MS. While carvacrol constitutes 50% as the main component of ZM, it was seen as 48.06% carvacrol and 25.47% thymol as a content area. It was analyzed that ZM has a total antioxidant rate of 99.87% with 20 components. In antibacterial tests, PLA/BAC/ZM NF showed the best inhibition growth on all microorganisms (Escherichia coli, Staphylococcus aureus, Bacillus cereus, Staphylococcus epidermidis, Bacillus subtilis). In cell XTT cytotoxicity tests, it was observed that the PLA/BAC/ZM NF used in adhesion and 4′,6-diamidino-2-phenylindole (DAPI) results showed very good adhesion to cells.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2021.2008391