Photo-regulated self-assembly and photo-tailored drug-release kinetics from a polymeric supramolecular nanocage

[Display omitted] •Photo was employed as a non-invasive tool in regulating the self-assembly and drug-release kinetics from a supramolecular nanocage in vitro and in vivo.•The supramolecular host–guest interaction can drive the formation of superamphiphile and advanced nanostructures.•This work coul...

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Bibliographic Details
Published in:European polymer journal 2022-09, Vol.178, p.111494, Article 111494
Main Authors: Xie, Zichen, Wu, Fupeng, Sun, Keyu
Format: Article
Language:English
Subjects:
Controllability
Cyclodextrins
Drug delivery systems
Drug release
Kinetics
Noninvasive
Phenytoin
Photo responsive
Polymers
Self-assembly
Supramolecular nanocage
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Summary:[Display omitted] •Photo was employed as a non-invasive tool in regulating the self-assembly and drug-release kinetics from a supramolecular nanocage in vitro and in vivo.•The supramolecular host–guest interaction can drive the formation of superamphiphile and advanced nanostructures.•This work could help narrow down the gap between concept and applications of supramolecular chemistry. In this work, a polymeric supramolecular nanocage was assembled from a host–guest superamphiphile composed by a comb-like poly-cyclodextrin and azo-functionalized prodrug. The design principle and preparation procedures were interpreted, while in vitro and in vivo experiments were undertaken to prove the concept. The nanocage can achieve a long circulation and slow drug-release kinetics, but the drug-release will be greatly accelerated upon transcutaneous photo irradiation. Hopefully, this work is useful in illustrating the construction of controllable drug-delivery systems employing non-invasive triggers.
ISSN:0014-3057
1873-1945
DOI:10.1016/j.eurpolymj.2022.111494