Versatile selective absorption-based optical fiber toward epinephrine detection

A versatile lossy mode resonance (LMR) sensor is developed for Epinephrine monitoring based on the state-of-the-art molecular imprinting technique over an optical fiber. The optical absorption concept of the LMR-based sensor is proven by incorporating an amino silane-functionalized graphene oxide (S...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2022-12, Vol.372, p.132551, Article 132551
Main Authors: Azargoshasb, Tahereh, Parvizi, Roghaieh, Navid, H. Ali, Parsanasab, Gholam-Mohammad, Heidari, Hadi
Format: Article
Language:English
Subjects:
Absorption
Biosensors
Catecholamine
Epinephrine
Graphene
Molecular imprinting
Neurotransmitters
Optical fibers
Sensors
Silicon dioxide
Structural analysis
Surface chemistry
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Summary:A versatile lossy mode resonance (LMR) sensor is developed for Epinephrine monitoring based on the state-of-the-art molecular imprinting technique over an optical fiber. The optical absorption concept of the LMR-based sensor is proven by incorporating an amino silane-functionalized graphene oxide (SiO2-NH2@GO) as an adhesive layer for grafting Epinephrine imprinting polydopamine (Ep-IPDA) as a sensing layer onto the optical fiber curved surface. The accurate structural and morphological characterization confirmed the rough crystalline and spherical particles for Ep-IPDA and SiO2-NH2-GO onto optical fiber curved surface, while spectroscopic analysis confirms the formation of imprinting polymer and desirable absorbance characteristics. The optimized probe exhibits an excellent performance with the maximum sensitivity within two intervals of 0.3–1 µM and 1–90 µM along with the linearity coefficient of R2 = 0.99 possessing a low limit of detection of 0.07 µM. Additionally, this sensor selectively detects Ep in the presence of other species and showed good recovery in human urine and injection samples. This work opens a new avenue for developing bio-inspired LMR-based optical fiber biosensors and could be further extended to detect other catecholamine neurotransmitters.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2022.132551