Inflammatory Myofibroblastic Tumor Mimicking a Cavitary Lesion in the Lung: A Case Report and a Comprehensive Literature Review

Inflammatory myofibroblastic tumors (IMTs) are a group of soft tissue neoplasms with a predilection for the lungs and abdominopelvic cavity, characterized by a mixture of fasciitis-like, compact spindle cells, hypocellular fibrous histologic patterns, and distinctive molecular features. Due to their...

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Published in:Curēus (Palo Alto, CA) CA), 2022-09, Vol.14 (9), p.e29193
Main Authors: Arunachalam, Janani, Radhakrishnan, Haripriya, Patel, Harsh, Johal, Gurleen K, Medarametla, Gnana Deepthi, Sheikh, Aaiyat, Mahmood, Syed Nazeer, Shah, Viray, Patel, Digantkumar, Changawala, Nisarg
Format: Article
Language:English
Subjects:
Biopsy
Bronchoscopy
Case reports
Cytokeratin
Fever
Hemoptysis
Lungs
Lymphocytes
Lymphoma
Medical diagnosis
Medical prognosis
Metastasis
Molecular weight
Patients
Radiation therapy
Sarcoma
Smooth muscle
Tomography
Tumors
Ultrasonic imaging
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Summary:Inflammatory myofibroblastic tumors (IMTs) are a group of soft tissue neoplasms with a predilection for the lungs and abdominopelvic cavity, characterized by a mixture of fasciitis-like, compact spindle cells, hypocellular fibrous histologic patterns, and distinctive molecular features. Due to their unspecified symptoms and non-specific radiologic presentation, the histopathologic and immunohistochemical analysis of a biopsy specimen is crucial for the diagnosis. We present a case of a 30-year-old man with intermittent hemoptysis diagnosed with a pulmonary IMT. We aim to review the literature regarding its definition, clinical findings, diagnosis, treatment, and prognosis. The treatment for an IMT is based on its location and extent, including complete surgical resection, which has a good prognosis compared to corticosteroids, chemotherapy, radiotherapy, and non-steroidal immunomodulation in patients who are not good surgical candidates. Further investigative studies with larger sample sizes and longer meticulous follow-ups are needed to demonstrate this neoplastic disease's natural history and find appropriate management for it.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.29193