Gestational Intraplacental Choriocarcinoma in a Term Pregnancy: A Case Report

Intraplacental choriocarcinoma (IC) is a rare type of gestational choriocarcinoma (GC) occurring within the placenta, and only a small number of cases have been reported so far. Intraplacental choriocarcinoma is usually asymptomatic or may present with aspecific symptoms, including unexplained vagin...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-11, Vol.14 (11), p.e31243
Main Authors: Sala, Andrea, Ornaghi, Sara, Delle Marchette, Martina, Bonazzi, Cristina Maria, Gorla, Sonia, Moltrasio, Francesca, Fruscio, Robert, Vergani, Patrizia, Landoni, Fabio
Format: Article
Language:English
Subjects:
Case reports
Chemotherapy
Hysterectomy
Medical prognosis
Metastasis
Obstetrics
Placenta
Pregnancy
Remission (Medicine)
Stains & staining
Surveillance
Tumors
Ultrasonic imaging
Uterus
Vagina
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Summary:Intraplacental choriocarcinoma (IC) is a rare type of gestational choriocarcinoma (GC) occurring within the placenta, and only a small number of cases have been reported so far. Intraplacental choriocarcinoma is usually asymptomatic or may present with aspecific symptoms, including unexplained vaginal bleeding during pregnancy. Early diagnosis and treatment are pivotal for ensuring optimal outcomes. However, intraplacental choriocarcinoma is rarely suspected due to limited knowledge and awareness of the condition. Here, we report the case of a 34-year-old woman diagnosed with intraplacental choriocarcinoma by placental histological examination performed after delivery due to unexplained vaginal bleeding at 29 gestational weeks, requiring hospital admission. Two lines of chemotherapy and surgery were necessary to achieve complete remission. Since unexplained vaginal bleeding during pregnancy can be a clinical manifestation of intraplacental choriocarcinoma, we propose to consider placental histological examination in all pregnancies with this complication.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.31243