Nanoplatform-Integrated Miniaturized Solid-Phase Extraction Techniques: A Critical Review

Preparation of the biological samples is one of the most critical steps in sample analysis. In past decades, the liquid-liquid extraction technique has been used to extract the desired analytes from complex biological matrices. However, solid-phase extraction (SPE) gained popularity due to versatili...

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Bibliographic Details
Published in:Critical reviews in analytical chemistry 2023, Vol.53 (1), p.46-68
Main Authors: Salve, Sushmita, Bahiram, Yogita, Jadhav, Amol, Rathod, Rajeshwari, Tekade, Rakesh Kumar
Format: Article
Language:English
Subjects:
Biological properties
Biological samples
Carbon-based nanosorbents
immunoaffinity magnetic solid-phase extraction
Liquid-liquid extraction
magnetic nanosorbents
Molecular Imprinting - methods
molecularly imprinted polymers
nanosorbents
Polymers
Reproducibility of Results
Sample preparation
Selectivity
Solid Phase Extraction - methods
Solid phases
Solvents
Specimen Handling
Technology
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Summary:Preparation of the biological samples is one of the most critical steps in sample analysis. In past decades, the liquid-liquid extraction technique has been used to extract the desired analytes from complex biological matrices. However, solid-phase extraction (SPE) gained popularity due to versatility, simplicity, selectivity, reproducibility, high sample recovery %, solvent economy, and time-saving nature. The superior extraction efficiency of SPE can be attributed to the development of advanced techniques, including the nanosorbents technology. The nanosorbent technology significantly simplified the sample preparation, improved the selectivity, diversified the application, and accelerated the sample analysis. This review critically expands on the to-date advancements reported in SPE with particular regards to the nanosorbent technology.
ISSN:1040-8347
1547-6510
DOI:10.1080/10408347.2021.1934651