Gastruloids: A Novel System for Disease Modelling and Drug Testing

By virtue of its inaccessible nature, mammalian implantation stage development has remained one of the most enigmatic and hard to investigate periods of embryogenesis. Derived from pluripotent stem cells, gastruloids recapitulate key aspects of gastrula-stage embryos and have emerged as a powerful i...

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Bibliographic Details
Published in:Stem cell reviews and reports 2023, Vol.19 (1), p.104-113
Main Authors: Amel, Atoosa, Rossouw, Simoné, Goolam, Mubeen
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Cell Biology
Congenital defects
Congenital diseases
Developmental stages
Drug testing
Embryo, Mammalian
Embryogenesis
Embryonic Development
Embryos
Gastrula
Growth factors
Heart
Life Sciences
Mammals
Morphogenesis
Pluripotency
Pluripotent Stem Cells
Regenerative Medicine/Tissue Engineering
Stem Cells
Teratogenicity
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Summary:By virtue of its inaccessible nature, mammalian implantation stage development has remained one of the most enigmatic and hard to investigate periods of embryogenesis. Derived from pluripotent stem cells, gastruloids recapitulate key aspects of gastrula-stage embryos and have emerged as a powerful in vitro tool to study the architectural features of early post-implantation embryos. While the majority of the work in this emerging field has focused on the use of gastruloids to model embryogenesis, their tractable nature and suitability for high-throughput scaling, has presented an unprecedented opportunity to investigate both developmental and environmental aberrations to the embryo as they occur in vitro. This review summarises the recent developments in the use of gastruloids to model congenital anomalies, their usage in teratogenicity testing, and the current limitations of this emerging field.
ISSN:2629-3269
2629-3277
DOI:10.1007/s12015-022-10462-5