A Novel Nitrogen-containing Glyceride from Fungal Saprobe Tubeufia rubra Reverses MDR of Tumor Cell Lines to Doxorubicin

AA chemical investigation of secondary metabolites from the saprobic fungus Tubeufia rubra led to isolation of a novel nitrogen-containing glyceride, Rubracin A (1), and a novel eight-membered cyclic ether carboxylate methyl ester, Rubracin H (2). Together with six known compounds (3-8). The chemica...

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Bibliographic Details
Published in:Records of natural products 2022-11, Vol.16 (5), p.1-11
Main Authors: Zeng, Xuebo, Qian, Shengyan, Lu, Yongzhong, Chen, Lizhuang, Qian, Yixin, He, Zhangjiang, Kang, Jichuan, Li, Yongjie
Format: Article
Language:English
Subjects:
Biotechnology
Cancer therapies
Chemotherapy
Chromatography
Cytotoxicity
Glycoproteins
Metabolites
Microorganisms
Nitrogen
Pharmaceuticals
Solvents
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Summary:AA chemical investigation of secondary metabolites from the saprobic fungus Tubeufia rubra led to isolation of a novel nitrogen-containing glyceride, Rubracin A (1), and a novel eight-membered cyclic ether carboxylate methyl ester, Rubracin H (2). Together with six known compounds (3-8). The chemical structure of these new compounds were elucidated by 1D and 2D NMR and HR-ESI-MS techniques. Although, there are no observed cytotoxic effects of compound 1 against MCF-7/Dox, A549/Dox, and K562/Dox cells at oncentrations below 25 μg/mL, usage of compound 1 and doxorubicin revealed the MDR reversal via decreased IC50 values than that of sole doxorubicin application in the cell lines. A preliminary Western Blot assay indicated that the MDR reversal of compound 1 was due to suppression of P-glycoprotein (P-gp) expression.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.320.2201.2334