Lactones from Glomerella cingulata Cultivated in Rice:Structural Studies and Antimicrobial Evaluation

Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1H and 13C NMR and HRMS. These analyzes allowed th...

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Bibliographic Details
Published in:Records of natural products 2023-01, Vol.17 (1), p.195-200
Main Authors: F. Gomes, Nayara, Júnior, Manoel Leão L., C. Filho, Antônio José, S. Santos, Lourivaldo, N. Silva, Luís Cláudio, Rodrigues-Filho, Edson
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
Chemistry
Chromatography
Fungi
Identification
Metabolites
Microorganisms
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Summary:Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1H and 13C NMR and HRMS. These analyzes allowed the identification of pestalotin-1 (1) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (2) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (3). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereoisomer 3 and pestalotin-1 were inactive.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.340.2202.2352