Lactones from Glomerella cingulata Cultivated in Rice:Structural Studies and Antimicrobial Evaluation

Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1H and 13C NMR and HRMS. These analyzes allowed th...

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Published in:Records of natural products 2023-01, Vol.17 (1), p.195-200
Main Authors: F. Gomes, Nayara, Júnior, Manoel Leão L., C. Filho, Antônio José, S. Santos, Lourivaldo, N. Silva, Luís Cláudio, Rodrigues-Filho, Edson
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Language:English
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Antimicrobial agents
Bacteria
Chemistry
Chromatography
Fungi
Identification
Metabolites
Microorganisms
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container_title Records of natural products
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creator F. Gomes, Nayara
Júnior, Manoel Leão L.
C. Filho, Antônio José
S. Santos, Lourivaldo
N. Silva, Luís Cláudio
Rodrigues-Filho, Edson
description Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1H and 13C NMR and HRMS. These analyzes allowed the identification of pestalotin-1 (1) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (2) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (3). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereoisomer 3 and pestalotin-1 were inactive.
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subjects Antimicrobial agents
Bacteria
Chemistry
Chromatography
Fungi
Identification
Metabolites
Microorganisms
title Lactones from Glomerella cingulata Cultivated in Rice:Structural Studies and Antimicrobial Evaluation
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