Lathyrane diterpenoids from Jatropha podagrica and their antitumor activities in human osteosarcoma cells

Two new lathyrane-type diterpenoids, jatropodagins A and B (1 and 2), and five known analogues (3-7), were isolated from the stems of Jatropha podagrica. Their structures and absolute configurations were elucidated by spectroscopic data and calculated ECD analyses. The cytotoxicities of all the lath...

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Bibliographic Details
Published in:Natural product research 2021-12, Vol.35 (23), p.5089-5095
Main Authors: Yuan, Han-Tao, Li, Qun-Feng, Tian, Tian, Zhang, Chun-Yan, Huang, Zou-Qin, Fan, Chun-Xiang, Mei, Ke, Zhou, Jie, Zhai, Xiao-Xiang, Li, Si-Bo, Zhu, Jian-Yong
Format: Article
Language:English
Subjects:
Anticancer properties
antitumor activity
Apoptosis
Cell lines
Cytotoxicity
Diterpenes
diterpenoid
Jatropha podagrica
lathyrane
Osteosarcoma
Osteosarcoma cells
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Summary:Two new lathyrane-type diterpenoids, jatropodagins A and B (1 and 2), and five known analogues (3-7), were isolated from the stems of Jatropha podagrica. Their structures and absolute configurations were elucidated by spectroscopic data and calculated ECD analyses. The cytotoxicities of all the lathyrane-type diterpenoids (1-7) were evaluated against two human osteosarcoma cell lines (Saos-2 and MG-63). Compound 1 exhibited significant cytotoxic effects against Saos-2 and MG-63 with IC 50 values of 8.08 and 14.64 μM, respectively. The IC 50 values for the positive control 5-FU against the Saos-2 and MG-63 cell lines were 19.01 and 25.00 μM, respectively. Morphological features of apoptosis activities were evaluated in 1-treated Saos-2 cells and the results confirmed apoptosis in a dose-dependent manner.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1779719