Structural hybrids of sulfonamide and thiazole moieties: Synthesis and evaluation of antimicrobial activity

For the discovery of new antimicrobial drugs, new derivatives of sulfonamide having thiazole ring were synthesized. The new series of sulfonamide derivatives were synthesized starting from 4-(arylsulfonamido)-acetophenone thiosemicarbazones 2a-f. Cyclization of thiosemicarbazone derivatives 2a-f by...

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Bibliographic Details
Published in:Synthetic communications 2023-01, Vol.53 (1), p.68-75
Main Authors: Abbas, Samir Y., Abd El-Aziz, Maha M., Awad, Samir M., Mohamed, Mosaad S.
Format: Article
Language:English
Subjects:
Acetophenone
Antiinfectives and antibacterials
Antimicrobial activity
Microorganisms
Sulfonamides
Synthesis
thiazoles
thiosemicarbazones
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Summary:For the discovery of new antimicrobial drugs, new derivatives of sulfonamide having thiazole ring were synthesized. The new series of sulfonamide derivatives were synthesized starting from 4-(arylsulfonamido)-acetophenone thiosemicarbazones 2a-f. Cyclization of thiosemicarbazone derivatives 2a-f by using ethyl chloroacetate and chloroacetone gave the thiazolidin-4-ones 3a-f and 4-methylthiazoles 4a-e, respectively. The antimicrobial properties of the synthesized compounds were investigated. The major thiosemicarbazone and thiazole derivatives gave no effect on most of the tested microorganisms. Incorporation phenyl group at both of the N-4 of thiosemicarbazones and the sulfonamide as in compound 2f gave moderate effects against most of the screened Gram-positive bacteria.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2022.2150086